{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T07:13:34Z","timestamp":1772781214024,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":5034,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1992,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Translocations involving 11q23 are recurring abnormalities in human acute leukemia cells of either lymphoid or myeloid lineage. Analysis of 13 variant translocations associated with four of these [t(4; 11), t(6; 11), t(9; 11) and t(11; 19)] reveals that the der(11) chromosome is conserved in all of them and therefore contains the critical genetic rearrangement. The <jats:italic>MLL<\/jats:italic> gene (myeloid\/ lymphoid leukemia) is involved in each of these translocations. It is transcribed from centromere to telomere. The present analysis indicates that the 5\u2032 region of <jats:italic>MLL<\/jats:italic> on the der(11) is juxtaposed to the coding sequences of genes on each of the other translocation partners.<\/jats:p>","DOI":"10.1002\/gcc.2870050316","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:09:24Z","timestamp":1172099364000},"page":"264-266","source":"Crossref","is-referenced-by-count":45,"title":["The der(II) chromosome contains the critical breakpoint junction in the 4;11, 9;11, and 11;19 translocations in acute leukemia"],"prefix":"10.1002","volume":"5","author":[{"given":"Janet D.","family":"Rowley","sequence":"first","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(85)90106-2"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90026-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1182\/blood.V78.10.2498.2498","article-title":"Breakpoint clustering in t(4;11)(q21;q23) acute leukemia","volume":"78","author":"Chen C\u2010S","year":"1991","journal-title":"Blood"},{"key":"e_1_2_1_5_1","first-page":"6712","article-title":"Cloning of ALL\u20101, the locus involved in leukemias with the t(4; 11)(q21;q23), t(9;11)(p22;q23), and t(11;19)(q23;p13) chromosome translocations","volume":"51","author":"Cimino G","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030103"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90108-2"},{"key":"e_1_2_1_8_1","first-page":"708","article-title":"Phenotypic and genotypic heterogeneity in infant acute leukemia. 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Clowes award lecture","volume":"50","author":"Rowley JD","year":"1990","journal-title":"Cancer Res"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9358"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1957167"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910380611"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.23.10735"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870050316","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870050316","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T16:20:41Z","timestamp":1698078041000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870050316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992,10]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1992,10]]}},"alternative-id":["10.1002\/gcc.2870050316"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870050316","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1992,10]]}}}