{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T03:15:57Z","timestamp":1772766957364,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4942,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deletions and\/or allelic losses of a portion of the long arm of chromosome 11 were discovered by cytogenetic and restriction fragment length polymorphism analyses in 23 of 39 (59%) informative cases of colorectal carcinoma. By comparing the patterns of loss of heterozygosity and chromosome rearrangements in different patients, we could map a common target region to 11q22\u201023. This region may contain a tumor suppressor gene, the inactivation of which may be involved in the development of tumors of the large intestine. The subgroup of malignancies with 11q alterations seemed to be enriched by tumors that were located in the rectum, that were Dukes' stage A, and that were well differentiated and mucin producing.\u00a9 1993 Wiley\u2010Liss,<\/jats:p>","DOI":"10.1002\/gcc.2870060109","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:09:09Z","timestamp":1172099349000},"page":"45-50","source":"Crossref","is-referenced-by-count":46,"title":["11q deletions in human colorectal carcinomas: Cytogenetics and restriction fragment length polymorphism analysis"],"prefix":"10.1002","volume":"6","author":[{"given":"Peter L.","family":"Keldysh","sequence":"first","affiliation":[]},{"given":"Tommaso A.","family":"Dragani","sequence":"additional","affiliation":[]},{"given":"Elena W.","family":"Fleischman","sequence":"additional","affiliation":[]},{"given":"Liliya N.","family":"Konstantinova","sequence":"additional","affiliation":[]},{"given":"Alexander G.","family":"Perevoschikov","sequence":"additional","affiliation":[]},{"given":"Marco A.","family":"Pierotti","sequence":"additional","affiliation":[]},{"given":"Giuseppe Della","family":"Porta","sequence":"additional","affiliation":[]},{"given":"Boris P.","family":"Kopnin","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90572-C"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90443-I"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1958.37"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030102"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132793"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00194640"},{"key":"e_1_2_1_8_1","volume-title":"Molecular Cloning: A Laboratory Manual","author":"Maniatis T","year":"1982"},{"key":"e_1_2_1_9_1","first-page":"565","article-title":"Localization of the HeLa cell tumor\u2010suppressor gene to the long arm of chromosome 11","volume":"45","author":"Misra BC","year":"1989","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(90)90100-O"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910390509"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.87.23.9358"},{"key":"e_1_2_1_13_1","first-page":"2960","article-title":"High rates of ras codon 61 mutation in thyroid tumors in an iodide\u2010deficient area","volume":"51","author":"Shi Y","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90328-0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2565047"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(89)90090-6"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870060109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870060109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T08:17:02Z","timestamp":1698308222000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870060109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,1]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1993,1]]}},"alternative-id":["10.1002\/gcc.2870060109"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870060109","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,1]]}}}