{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T08:12:39Z","timestamp":1760170359425},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4761,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Forty\u2010six cases of sporadic melanoma have been investigated for loss of heterozygosity at 4 loci: D11S29 (11q23), <jats:italic>YNZ22<\/jats:italic> (17p13.3), <jats:italic>TP53<\/jats:italic> (17p13.1); and <jats:italic>NM23<\/jats:italic> (17q22). Each of the loci is thought to be important in the pathogenesis of other tumours. Mutations were found infrequently at the <jats:italic>YNZ22, NM23<\/jats:italic>, and <jats:italic>TP53<\/jats:italic> loci. At D11S29, however, the frequency of mutation in the melanoma samples was high (67%) and mutations at this locus were associated with younger age at presentation. This region of chromosome 11 is also commonly mutated in breast cancers and haematological malignancies. Genetic aberrations at D11S29 may therefore represent nonspecific mutations found in several malignancies or part of a pathway common to the malignant phenotype. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870070310","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:42:09Z","timestamp":1172101329000},"page":"169-172","source":"Crossref","is-referenced-by-count":38,"title":["Loss of heterozygosity in malignant melanoma at loci on chromosomes 11 and 17 implicated in the pathogenesis of other cancers"],"prefix":"10.1002","volume":"7","author":[{"given":"I. P. M.","family":"Tomlinson","sequence":"first","affiliation":[]},{"given":"A. J.","family":"Gammack","sequence":"additional","affiliation":[]},{"given":"J. E.","family":"Stickland","sequence":"additional","affiliation":[]},{"given":"G. J.","family":"Mann","sequence":"additional","affiliation":[]},{"given":"R. M.","family":"Mackie","sequence":"additional","affiliation":[]},{"given":"R. F.","family":"Kefford","sequence":"additional","affiliation":[]},{"given":"J. O'D.","family":"McGee","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439824"},{"key":"e_1_2_1_3_1","first-page":"1059","article-title":"Frequent loss of heterozygosity on chromosome 18 in ovarian adenocarcinoma which does not always include the DCC locus","volume":"7","author":"Chevenix\u2010Trench G","year":"1992","journal-title":"Oncogene"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.12.4614"},{"key":"e_1_2_1_5_1","first-page":"645","article-title":"Genetics of melanoma","volume":"9","author":"Fountain JW","year":"1990","journal-title":"Cancer Surv"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90186-0"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(88)90584-3"},{"key":"e_1_2_1_8_1","first-page":"5449","article-title":"Loss of heterozygosity for loci on the long arm of chromosome 6 in human malignant melanoma","volume":"51","author":"Millikin D","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90112-L"},{"key":"e_1_2_1_10_1","first-page":"883","article-title":"Allele losses in malignant melanoma reflect random events","volume":"10","author":"Nordenskj\u00f6ld M","year":"1990","journal-title":"Anticancer Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep13076687"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90103-2"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/342177a0"},{"key":"e_1_2_1_14_1","first-page":"3","article-title":"Allelic loss on chromosome 11q is a frequent event in breast cancer","volume":"66","author":"Stickland JE","year":"1992","journal-title":"Br J Cancer"},{"key":"e_1_2_1_15_1","first-page":"5976","article-title":"Expression of mutant p53 in melanoma","volume":"51","author":"Stretch JR","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/20.1.145"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870070310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870070310","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:12:40Z","timestamp":1698261160000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870070310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993,7]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1993,7]]}},"alternative-id":["10.1002\/gcc.2870070310"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870070310","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1993,7]]}}}