{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:36:50Z","timestamp":1763746610407},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1993,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cytogenetic analysis was performed on a selected series of short\u2010term cultures of primary breast carcinomas from 28 patients. All patients had histopathologically confirmed malignancies, with the majority (25\/28 cases) demonstrating infiltrating ductal carcinoma. All 28 cases evidenced clonal chromosome abnormalities, with 10\/28 displaying only numeric aberrations, whereas 18\/28 displayed clonal structural alterations. In near\u2010diploid tumors the most common numeric changes were \u2014 17 and \u2014 19. However, trisomy 7 was the only numeric change in two near\u2010diploid tumors. Structural chromosome alterations were primarily isochromosomes, apparent terminal deletions, and unbalanced non\u2010reciprocal translocations. Chromosomes 1 (10\/18\u201356%) and 6 (8\/18\u201344%) were most frequently altered in this series. Breakpoints of clonal structural abnormalities were shown to cluster to several chromosome segments, including 1p22\u2010q11, 3p11, 6p11\u201313, 7p11\u2010q11, 8p11\u2010q11, and 19q13. Analysis of the gain or loss of specific chromosome segments revealed that the most consistent tendency was over\u2010representation of 1q, 3q, and 6p. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870070402","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:38:56Z","timestamp":1172101136000},"page":"185-193","source":"Crossref","is-referenced-by-count":69,"title":["Clonal chromosome abnormalities in human breast carcinomas I. Twenty\u2010eight cases with primary disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Floyd","family":"Thompson","sequence":"first","affiliation":[]},{"given":"Julia","family":"Emerson","sequence":"additional","affiliation":[]},{"given":"William","family":"Dalton","sequence":"additional","affiliation":[]},{"given":"Jin\u2010Ming","family":"Yang","sequence":"additional","affiliation":[]},{"given":"Daniel","family":"McGee","sequence":"additional","affiliation":[]},{"given":"Hugo","family":"Villar","sequence":"additional","affiliation":[]},{"given":"Sally","family":"Knox","sequence":"additional","affiliation":[]},{"given":"Kathy","family":"Massey","sequence":"additional","affiliation":[]},{"given":"Ronald","family":"Weinstein","sequence":"additional","affiliation":[]},{"given":"Achyut","family":"Bhattacharyya","sequence":"additional","affiliation":[]},{"given":"Jeffrey","family":"Trent","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","unstructured":"American Cancer Society(1992) Cancer Facts and Figures Atlanta Georgia."},{"key":"e_1_2_1_3_1","volume-title":"Manual for Staging of Cancer","author":"American Joint Committee on Cancer","year":"1988"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(82)90010-3"},{"key":"e_1_2_1_5_1","first-page":"1705","article-title":"Allelotype of human breast carcinoma. 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