{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:35:51Z","timestamp":1760297751452},"reference-count":23,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4577,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Although abnormalities of chromosome 6 have frequently been observed in Burkitt's lymphoma (BL), they have 50 far not been defined by modern cytogenetic and molecular methods. By a combination of high\u2010resolution chromosome banding, fluorescence in situ hybridization (FISH), and loss of heterozygosity (LOH) analysis, we have examined the nature of aberrations affecting chromosome 6 in 7 previously established BL cell lines. All cell lines exhibited the characteristic translocations associated with BL; 5 had t(814)(q24;q32) and 2 had t(8;22)(q24;q11). Three cell lines had deletions of 6q; 3 others had rearrangements affecting 6q, whereas one cell line had apparently normal chromosomes 6. FISH analysis of the three deletions established that they were interstitial. LOH analysis with probes mapped to the 6q26\u201027 region confirmed the sub\u2010telomeric interstitial deletion in cell line BL\u2010108, which had a del(6)(q23q27). All informative loci mapped to 6q26\u201027 (5\/7) were deleted in BL\u201074, which had no apparent cytogenetic abnormality in chromosome 6, thus documenting a sub\u2010microscopic deletion. These data define the cytogenetic and molecular limits of 6q deletions in BL and are consistent with our previous demonstration of LOH analysis of the site of a candidate tumor suppressor gene in the 6q25\u201027 region. <jats:italic>Genes Chrom Cancer 9:13\u201018 (1994).<\/jats:italic> \u00a91994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870090104","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T23:45:55Z","timestamp":1172101555000},"page":"13-18","source":"Crossref","is-referenced-by-count":28,"title":["Cytogenetic and molecular analysis of 6q deletions in burkitt's lymphoma cell lines"],"prefix":"10.1002","volume":"9","author":[{"given":"Nasser Z.","family":"Parsa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asit B.","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. S. K.","family":"Chaganti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S.","family":"Hauptschein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Riccardo","family":"Dalla\u2010Favera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilbert","family":"Lenoir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(90)90037-U"},{"key":"e_1_2_1_3_1","first-page":"1187","article-title":"Cytogenetic study of a European Burkitt's lymphoma cell line","volume":"62","author":"Berger R","year":"1979","journal-title":"J Natl Cancer Inst"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(83)90138-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(81)90060-8"},{"key":"e_1_2_1_6_1","first-page":"1269","article-title":"Specific translocations characterize Burkitt's\u2010like lymphoma of homosexual men","volume":"61","author":"Chaganti RSK","year":"1983","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.12.5413"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood.V80.7.1781.1781","article-title":"Deletions involving two distinct regions of 6q in B\u2010cell non\u2010Hodgkin's lymphoma","volume":"80","author":"Gaidano G","year":"1992","journal-title":"Blood"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132030"},{"key":"e_1_2_1_10_1","volume-title":"Supplement to an International System for Human Cytogenetic Nomenclature","author":"ISCN","year":"1991"},{"key":"e_1_2_1_11_1","first-page":"63","article-title":"The contribution of Burkitt's lymphoma cell lines to the understanding of the pathogenesis of Burkitt's lymphoma","volume":"10","author":"Kiwanuka J","year":"1988","journal-title":"Cancer Rev"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/237033a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1979.tb01288.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/16.3.1215"},{"key":"e_1_2_1_15_1","first-page":"526","article-title":"Role of the pseudoautosomal region in sexchromosome pairing during male meiosis: Meiotic studies in a man with a deletion of distal Xp","volume":"51","author":"Mohandas TK","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.18.6622"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90076-B"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1439770"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870030304"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1993.1206"},{"key":"e_1_2_1_21_1","first-page":"65","article-title":"Isolation and mapping of 68 RFLP markers on human chromosome 6","volume":"50","author":"Saito S","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0888-7543(91)90110-Z"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133727"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910170108"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870090104","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870090104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T05:12:20Z","timestamp":1698124340000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870090104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,1]]},"references-count":23,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1994,1]]}},"alternative-id":["10.1002\/gcc.2870090104"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870090104","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,1]]}}}