{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T15:45:12Z","timestamp":1762271112442},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4487,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The human homolog of the murine double minute type 2 gene (<jats:italic>MDM2<\/jats:italic>) has been cloned and mapped to 12q 13\u201014. The gene presumably functions as a cellular regulator and mediator of TP53 function. Amplification of the <jats:italic>MDM2<\/jats:italic> gene has recently been observed in soft tissue sarcoma and in osteosarcoma. We studied <jats:italic>MDM2<\/jats:italic> amplification in a series of 94 mesenchymal tumors and found 3\u201020\u2010fold amplification in 20 tumors: in 10 of 49 malignant fibrous histiocytomas (MFH), in 1 of 2 pleomorphic liposarcomas, in 6 of 7 atypical lipomas, and in 3 of 12 typical lipomas. Normal hybridization patterns were detected in all 16 myxoid liposarcomas, in all 3 leiomyosarcomas, and in all 5 leiomyomas studied. The <jats:italic>MDM2<\/jats:italic> amplification correlated with the presence of marker ring chromosomes; of the 10 MFH with <jats:italic>MDM2<\/jats:italic> amplification, 5 had ring chromosomes, compared to 4 of 39 without <jats:italic>MDM2<\/jats:italic> amplification, and all 9 lipomas with <jats:italic>MDM2<\/jats:italic> amplification had ring chromosomes, in 5 of the tumors as the sole karyotypic anomaly. The correlation between ring chromosomes and <jats:italic>MDM2<\/jats:italic> gene amplification indicates that the marker rings of MFH and of atypical lipoma often harbor genetic material derived from chromosome 12. <jats:italic>Genes Chrom Cancer 9:26 1\u2010265 (1994).<\/jats:italic> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870090406","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:16:37Z","timestamp":1172103397000},"page":"261-265","source":"Crossref","is-referenced-by-count":80,"title":["MDM2 gene amplification correlates with ring chromosomes in soft tissue tumors"],"prefix":"10.1002","volume":"9","author":[{"given":"Mef","family":"Nilbert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Mitelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nils","family":"Mandahl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anders","family":"Rydholm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena","family":"Will\u00e9n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050403"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000132513"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00288260"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-5223.1989.tb00787.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90001-3"},{"key":"e_1_2_1_7_1","volume-title":"Soft Tissue Tumors","author":"Enzinger FM","year":"1988"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1002\/j.1460-2075.1991.tb07676.x","article-title":"Tumorigenic potential associated with enhanced expression of a gene that is amplified in a mouse tumor cell line","volume":"10","author":"Fakhamdeh SS","year":"1991","journal-title":"EMBO J"},{"key":"e_1_2_1_9_1","first-page":"16","article-title":"MDM2gene amplification in metastatic osteosarcoma","volume":"53","author":"Ladanyi M","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_10_1","first-page":"2231","article-title":"p53mutation and MDM2amplification in human soft tissue sarcomas","volume":"53","author":"Leach TS","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00366238"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870010104"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","unstructured":"MandahlN H\u00f6glundM MertensF RydholmA Will\u00e9nH Brosj\u00f6O MitelmanF(1993)Cytogenetic aberrations in 188 benign and borderline adipose tissue tumors. Genes Chrom Cancer in press.","DOI":"10.1002\/gcc.2870090309"},{"key":"e_1_2_1_14_1","first-page":"495","article-title":"Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors","volume":"2","author":"Meltzer PS","year":"1991","journal-title":"Cell Growth Differ"},{"key":"e_1_2_1_15_1","volume-title":"Catalog of Chromosome Aberrations in Cancer","author":"Mitelman F","year":"1991"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90644-R"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870020103"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/358080a0"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/362857a0"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90011-V"},{"key":"e_1_2_1_21_1","doi-asserted-by":"crossref","unstructured":"\u00d6rndalC MandahlN Will\u00e9nH RydholmA MitelmanF(1993b)Cytogenetic evolution in primary tumors local recurrences and pulmonary metastases of two soft tissue sarcomas. 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