{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:57:08Z","timestamp":1760245028056},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4487,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1994,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Well\u2010differentiated liposarcomas (WDLPS) are frequently characterized by a near\u2010diploid karyotype with supernumerary ring and\/or giant rod\u2010shaped marker chromosomes. We have shown, using fluorescence in situ hybridization (FISH) and molecular strategies, that these markers contain chromosome 12\u2010derived sequences. Here we report the analysis of six WDLPS for the presence of amplified DNA segments by means of the recently developed comparative genomic hybridization (CGH) strategy. Two distinct chromosome 12\u2010derived amplification units could be identified in all tumors examined, one located in the q 14\u2010q 15 region as expected, the second unexpectedly mapping to q21.3\u2010q22. Our results indicate that the concerted amplification of these two distinct regions on the long arm of chromosome 12 may be a consistent characteristic of WDLPS. These amplifications are most likely directly related to the presence of supernumerary ring and\/or giant marker chromosomes in this group of soft tissue tumors. <jats:italic>Genes Chrom Cancer 9:292\u2010295 (1994).<\/jats:italic> \u00a9 1994 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gcc.2870090410","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:16:37Z","timestamp":1172103397000},"page":"292-295","source":"Crossref","is-referenced-by-count":53,"title":["Comparative genomic hybridization as a tool to define two distinct chromosome 12\u2010derived amplification units in well\u2010differentiated liposarcomas"],"prefix":"10.1002","volume":"9","author":[{"given":"Ron F.","family":"Suijkerbuijk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E. M. Olde","family":"Weghuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margot","family":"Van Den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ad Geurts","family":"Van Kessel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"Pedeutour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Turc\u2010Carel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Forus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ola","family":"Myklebost","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cliff","family":"Glier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870050403"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133416"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"Dal CinP KoolsP.SciotR De WeverI Van DammeB Van de VenW Van Den BergheH(1993)Cytogenetic and fluorescence in situ hybridization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet(in press).","DOI":"10.1016\/0165-4608(93)90001-3"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00202476"},{"key":"e_1_2_1_6_1","first-page":"1977","article-title":"The genes for the alph\u20102\u2010macroglobulin receptor\/LDL receptor related protein and GLI are located within a chromosomal segment of about 300 kb and are coamplified in a rhabdomyosarcoma cell line","volume":"58","author":"Forus A","year":"1991","journal-title":"Cytogenet Cell Genet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_1_8_1","first-page":"495","article-title":"Identification and amplification of a novel amplified sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors","volume":"2","author":"Meltzer PS","year":"1991","journal-title":"Cell Growth Differ"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90271-M"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/358080a0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90245-H"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000133462"},{"key":"e_1_2_1_13_1","first-page":"3746","article-title":"SAS amplification in soft tissue sarcomas","volume":"52","author":"Smith SH","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19920515)69:10<2484::AID-CNCR2820691017>3.0.CO;2-2"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90075-J"},{"key":"e_1_2_1_16_1","first-page":"269","article-title":"Demonstration of the genuine iso\u201012p character of the standard marker chromosome of testicular germ cell tumors and identification of further chromosome 12 aberrations by competitive in situ hybridization","volume":"48","author":"Suijkerbuijk RF","year":"1991","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(92)90056-E"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","unstructured":"SuijkerbuijkRF MeloniAM SinkeRJ ParringtonJM de JongB OosterhuisJW SandbergAA Geurts van KesselA(1993) Over\u2010representation of chromosome 12p sequences and karyotypic evolution in i(12p)\u2010negative testicular germ cell tumors revealed by fluorescence in situ hybridization.Cancer Genet Cytogenet(in press).","DOI":"10.1016\/0165-4608(93)90173-J"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870090410","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870090410","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,24]],"date-time":"2023-10-24T01:57:42Z","timestamp":1698112662000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870090410"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994,4]]}},"alternative-id":["10.1002\/gcc.2870090410"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870090410","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1994,4]]}}}