{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T20:18:09Z","timestamp":1772741889919,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,14]],"date-time":"2006-07-14T00:00:00Z","timestamp":1152835200000},"content-version":"vor","delay-in-days":4153,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genes Chromosomes &amp; Cancer"],"published-print":{"date-parts":[[1995,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Comparative genomic hybridization (CGH) makes it possible to detect losses and gains of DNA sequences along all chromosomes in a tumor specimen based on the hybridization of differentially labeled tumor and normal DNA to normal human metaphase chromosomes. In this study, CGH analysis was applied to the identification of genomic imbalances in 26 bladder cancers in order to gain information on the genetic events underlying the development and progression of this malignancy. Losses affecting 11p, 11q, 8p, 9, 17p, 3p, and 12q were all seen in more than 20% of the tumors. The minimal common region of loss in each chromosome was identified based on the analysis of overlapping deletions in different tumors. Gains of DNA sequences were most often found at chromosomal regions distinct from the locations of currently known oncogenes. The bands involved in more than 10% of the tumors were 8q21, 13q21\u2010q34, 1q31, 3q24\u2010q26, and 1p22. In conclusion, these CGH data highlight several previously unreported genetic alterations in bladder cancer. Further detailed studies of these regions with specific molecular genetic techniques may lead to the identification of tumor suppressor genes and oncogenes that play an important role in bladder tumorigenesis.<\/jats:p>","DOI":"10.1002\/gcc.2870120309","type":"journal-article","created":{"date-parts":[[2007,2,22]],"date-time":"2007-02-22T00:13:34Z","timestamp":1172103214000},"page":"213-219","source":"Crossref","is-referenced-by-count":159,"title":["Identification of gains and losses of DNA sequences in primary bladder cancer by comparative genomic hybridization"],"prefix":"10.1002","volume":"12","author":[{"given":"Anne","family":"Kallioniemi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olli\u2010P.","family":"Kallioniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gil","family":"Citro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Sauter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Devries","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Kerschmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Caroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fred","family":"Waldman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,14]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"6800","article-title":"Tumor behavior in transitional cell carcinoma of the bladder in relation to chromosomal markers and histopathology","volume":"47","author":"Babu VR","year":"1987","journal-title":"Cancer Res"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(86)90145-7"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30361-7"},{"key":"e_1_2_1_5_1","first-page":"1230","article-title":"Preliminary mapping of the deleted region of chromosome 9 in bladder cancer","volume":"53","author":"Cairns P","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)91595-D"},{"key":"e_1_2_1_7_1","first-page":"1705","article-title":"Allelotype of human breast carcinoma: A second major site for loss of heterozygosity on chromosome 6q","volume":"6","author":"Devilee P","year":"1991","journal-title":"Oncogene"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00202476"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1993.51"},{"key":"e_1_2_1_10_1","first-page":"1257","article-title":"Nonrandom chromosomal changes in transitional cell carcinoma of the bladder","volume":"44","author":"Gibas Z","year":"1984","journal-title":"Cancer Res"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530409"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1359641"},{"key":"e_1_2_1_13_1","first-page":"41","article-title":"Comparative genomic hybridization: A rapid new method for detecting and mapping of DNA amplification in tumors","volume":"4","author":"Kallioniemi O\u2010P","year":"1993","journal-title":"Semin Cancer Biol"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.6.2156"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.2870100403"},{"key":"e_1_2_1_16_1","first-page":"1357","article-title":"Deletion mapping of chromosome 8 in cancers of the urinary bladder using restriction fragment length polymorphisms and microsatellite polymorphisms","volume":"8","author":"Knowles MA","year":"1993","journal-title":"Oncogene"},{"key":"e_1_2_1_17_1","first-page":"531","article-title":"Allelotype of human bladder cancer","volume":"54","author":"Knowles MA","year":"1994","journal-title":"Cancer Res"},{"key":"e_1_2_1_18_1","first-page":"3474","article-title":"Deletion of chromosome 17p loci in breast cancer detected by fluorescence in situ hybridization","volume":"52","author":"Matsumura K","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_19_1","first-page":"820","article-title":"Allelotype of renal carcinoma","volume":"51","author":"Morita R","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_20_1","unstructured":"PiperJ RutovitzD SudarD KallioniemiA KallioniemiO\u2010P WaldmanFM GrayJW PinkelD(1994)Computer image analysis of comparative genomic hybridization. Cytometry (in press)."},{"key":"e_1_2_1_21_1","first-page":"356","article-title":"Comparative genomic hybridization and loss of heterozygosity studies in ovarian cancer","volume":"53","author":"Sakamoto M","year":"1993","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_22_1","first-page":"2926","article-title":"Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas","volume":"51","author":"Sano T","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_23_1","first-page":"5118","article-title":"Allelotype of human ovarian cancer","volume":"51","author":"Sato T","year":"1991","journal-title":"Cancer Res"},{"key":"e_1_2_1_24_1","first-page":"2199","article-title":"Heterogeneity of erbB\u20102 amplification in bladder cancer","volume":"53","author":"Sauter G","year":"1993","journal-title":"Cancer Res"},{"key":"e_1_2_1_25_1","first-page":"756","article-title":"Physical deletion of the p53 gene in bladder cancer: Detection by fluorescence in situ hybridization","volume":"144","author":"Sauter G","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","unstructured":"SauterG MochH CarrollP KerschmannR MihatschM WaldmanF(1994b)Chromosome 9 loss detected by fluorescence in situ hybridization in bladder cancer. Am J Pathol (in press).","DOI":"10.1002\/ijc.2910640205"},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(87)90028-8"},{"key":"e_1_2_1_28_1","first-page":"2478","article-title":"Allelotype of non\u2010small cell lung carcinoma\u2014Comparison between loss of heterozygosity in squamous cell carcinoma and adenocarcinoma","volume":"52","author":"Tsuchiya E","year":"1992","journal-title":"Cancer Res"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(88)90090-8"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(17)37212-9"}],"container-title":["Genes, Chromosomes and Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgcc.2870120309","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gcc.2870120309","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,11]],"date-time":"2024-02-11T04:20:30Z","timestamp":1707625230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gcc.2870120309"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":29,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/gcc.2870120309"],"URL":"https:\/\/doi.org\/10.1002\/gcc.2870120309","archive":["Portico"],"relation":{},"ISSN":["1045-2257","1098-2264"],"issn-type":[{"value":"1045-2257","type":"print"},{"value":"1098-2264","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}