{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T10:46:54Z","timestamp":1763808414944},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2003,6,27]],"date-time":"2003-06-27T00:00:00Z","timestamp":1056672000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genesis"],"published-print":{"date-parts":[[2003,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Summary: The patched gene (<jats:italic>Ptc<\/jats:italic>) is a member of the hedgehog signaling pathway which plays a central role in the development of many invertebrate and vertebrate tissues. In addition, <jats:italic>Ptc<\/jats:italic> and a number of other pathway members are mutated in some common human cancers. Patched is the receptor for the hedgehog ligand and in the mouse ablation of the <jats:italic>Ptc<\/jats:italic> gene leads to developmental defects and an embryonic lethal phenotype. Here we describe a conditional <jats:italic>Ptc<\/jats:italic> allele in mice which will have utility for the temporospatial ablation of <jats:italic>Ptc<\/jats:italic> function. genesis 36:158\u2013161, 2003. \u00a9 2003 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gene.10208","type":"journal-article","created":{"date-parts":[[2003,7,15]],"date-time":"2003-07-15T10:08:54Z","timestamp":1058263734000},"page":"158-161","source":"Crossref","is-referenced-by-count":94,"title":["<i>Patched 1<\/i> conditional null allele in mice"],"prefix":"10.1002","volume":"36","author":[{"given":"Tammy","family":"Ellis","sequence":"first","affiliation":[]},{"given":"Ian","family":"Smyth","sequence":"additional","affiliation":[]},{"given":"Emily","family":"Riley","sequence":"additional","affiliation":[]},{"given":"Scott","family":"Graham","sequence":"additional","affiliation":[]},{"given":"Kate","family":"Elliot","sequence":"additional","affiliation":[]},{"given":"Monica","family":"Narang","sequence":"additional","affiliation":[]},{"given":"Graham F.","family":"Kay","sequence":"additional","affiliation":[]},{"given":"Carol","family":"Wicking","sequence":"additional","affiliation":[]},{"given":"Brandon","family":"Wainwright","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2003,6,27]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.2.e29"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182542899"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00056-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.20.10992"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.10.3.301"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5329.1109"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(18)30114-1"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81268-4"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(00)00755-7"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.272.5268.1668"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00129-X"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3563490"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/332371a0"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/384176a0"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(01)00229-9"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)80018-9"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/75973"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/23.24.5080"},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320500312"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/384129a0"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature00989"},{"key":"e_1_2_1_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9297(07)62934-6"},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1203282"}],"container-title":["genesis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgene.10208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gene.10208","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T02:47:14Z","timestamp":1700189234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gene.10208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,6,27]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,7]]}},"alternative-id":["10.1002\/gene.10208"],"URL":"https:\/\/doi.org\/10.1002\/gene.10208","archive":["Portico"],"relation":{},"ISSN":["1526-954X","1526-968X"],"issn-type":[{"value":"1526-954X","type":"print"},{"value":"1526-968X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,6,27]]}}}