{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T13:43:36Z","timestamp":1770990216494,"version":"3.50.1"},"reference-count":17,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,5,2]],"date-time":"2005-05-02T00:00:00Z","timestamp":1114992000000},"content-version":"vor","delay-in-days":7426,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1985,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An analytical study is conducted of the properties of statistical tests to detect linkage between a disease locus and a very polymorphic marker locus when data on sib pairs are available. In most instances the most powerful test is the test based on the mean number of marker alleles shared identical by descent by the two members of a sib pair, and the most efficient sampling strategy is almost always to sample only pairs with both sibs affected. We show it is valid to use the information from all possible sib pairs as though they came from separate families when data on sibships of size three or larger are available, though more power may be obtained if different weights are given to the different sibship sizes.<\/jats:p>","DOI":"10.1002\/gepi.1370020109","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T21:37:54Z","timestamp":1118525874000},"page":"85-97","source":"Crossref","is-referenced-by-count":281,"title":["A comparison of sib\u2010pair linkage tests for disease susceptibility loci"],"prefix":"10.1002","volume":"2","author":[{"given":"William C.","family":"Blackwelder","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert C.","family":"Elston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. C.","family":"Rao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,2]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"214","volume-title":"A Course in Probability Theory","author":"Chung KL","year":"1974"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5976.133"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1976.tb00560.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)91975-9"},{"key":"e_1_2_1_6_1","first-page":"308","article-title":"A robust method for the detection of linkage in familial diseases","volume":"30","author":"Fishman PM","year":"1978","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1977.tb01076.x"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01066731"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370010203"},{"key":"e_1_2_1_10_1","volume-title":"First Course in Population Genetics","author":"Li CC","year":"1976"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1538-7305.1948.tb01338.x"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1978.tb01303.x"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1976.tb00186.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320120309"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-1809.1978.tb00933.x"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320180117"},{"key":"e_1_2_1_17_1","volume-title":"Histocompatibility Testing 1980","author":"Terasaki PI","year":"1980"},{"key":"e_1_2_1_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198111263052201"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370020109","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370020109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T17:33:04Z","timestamp":1697823184000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370020109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,1]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,1]]}},"alternative-id":["10.1002\/gepi.1370020109"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370020109","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1985,1]]}}}