{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T03:45:59Z","timestamp":1760586359968},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,6,3]],"date-time":"2005-06-03T00:00:00Z","timestamp":1117756800000},"content-version":"vor","delay-in-days":5997,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1989,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Analysis of the Fifth Genetic Analysis Workshop (GAW5) insulin\u2010dependent diabetes mellitus (IDDM) data leads to the following conclusions: (1) With a maximum\u2010likelihood affected sib pair method, there is strong evidence for linkage with HLA and no evidence for linkage with INS, Gm, or Km. (2) Susceptibility as defined by HLA genotypes is very complex. Each DR allele has a unique susceptibility, and DR3 and DR4 haplotype associations for DR 3\/4 genotypes are different from those for 3\/X and 4\/X. (3) Risk is substantially higher in sibships with an affected father compared to those with an affected mother. This excess cannot be attributed to transmission distortion at HLA.<\/jats:p>","DOI":"10.1002\/gepi.1370060127","type":"journal-article","created":{"date-parts":[[2005,6,11]],"date-time":"2005-06-11T13:58:06Z","timestamp":1118498286000},"page":"143-148","source":"Crossref","is-referenced-by-count":38,"title":["Genetics of IDDM: Evidence for complex inheritance with HLA"],"prefix":"10.1002","volume":"6","author":[{"given":"Neil","family":"Risch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,6,3]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-69770-8_268"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370030507"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370010203"},{"key":"e_1_2_1_5_1","first-page":"148","article-title":"The affected sib\u2010pair method using identity by state relations. (Letter to the editor)","volume":"39","author":"Lange K","year":"1986","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_6_1","first-page":"363","article-title":"Segregation analysis incorporating linkage markers. I. Single locus models with an application to type 1 diabetes","volume":"36","author":"Risch N","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370030759"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Assessing the role of HLA\u2010linked and unlinked determinants of disease","volume":"40","author":"Risch N","year":"1987","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_9_1","first-page":"1308","article-title":"HLA DR antigens and susceptibility to insulin\u2010dependent diabetes mellitus","volume":"36","author":"Thomson G","year":"1984","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_10_1","first-page":"207","article-title":"Determining the mode of inheritance of RFLP\u2010associated diseases using the affected sib\u2010pair method","volume":"39","author":"Thomson G","year":"1986","journal-title":"Am J Hum Genet"}],"container-title":["Genetic Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fgepi.1370060127","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/gepi.1370060127","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T01:21:32Z","timestamp":1694568092000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/gepi.1370060127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1989,1]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1989,1]]}},"alternative-id":["10.1002\/gepi.1370060127"],"URL":"https:\/\/doi.org\/10.1002\/gepi.1370060127","archive":["Portico"],"relation":{},"ISSN":["0741-0395","1098-2272"],"issn-type":[{"value":"0741-0395","type":"print"},{"value":"1098-2272","type":"electronic"}],"subject":[],"published":{"date-parts":[[1989,1]]}}}