{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:43:59Z","timestamp":1762098239935},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,6,5]],"date-time":"2005-06-05T00:00:00Z","timestamp":1117929600000},"content-version":"vor","delay-in-days":4538,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Genetic Epidemiology"],"published-print":{"date-parts":[[1993,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A sample enriched for familial combined hyperlipidemia (FCHL) was examined for evidence of an association between genotype at an apolipoprotein B (apoB) elevating locus defined by complex segregation analysis and FCHL. Complex segregation analysis detected a locus with a large effect on plasma apoB levels and was used to compute the most probable genotype of family members. None of the 35 normolipidemic adults carried a copy of the allele associated with elevated apoB levels, yet 58% of the 109 adults with FCHL carried 1 (29%) or 2 (28%) copies. Two of 28 (7%) normal children had 1 copy of this allele and none had 2 copies, while 88 of 182 (48%) children with FCHL had 1 (26%) or 2 (22%) copies. Further, 4l of 48 (85%) individuals classified as having hyperapobetalipoproteinemia did not carry a copy of this \u201celevated apoB\u201d allele. Therefore, the presence of the allele associated with elevation of apoB level is highly predictive of FCHL and this association cannot be explained solely by the presence of elevated apoB levels in FCHL, suggesting that the locus controlling apoB levels may play an etiologic role in FCHL. \u00a9 1993 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/gepi.1370100406","type":"journal-article","created":{"date-parts":[[2005,6,12]],"date-time":"2005-06-12T01:36:34Z","timestamp":1118540194000},"page":"257-270","source":"Crossref","is-referenced-by-count":22,"title":["Genotype at a major locus with large effects on apolipoprotein B levels predicts familial combined hyperlipidemia"],"prefix":"10.1002","volume":"10","author":[{"given":"Gail Pairitz","family":"Jarvik","sequence":"first","affiliation":[]},{"given":"Terri H.","family":"Beaty","sequence":"additional","affiliation":[]},{"given":"Paul R.","family":"Gallagher","sequence":"additional","affiliation":[]},{"given":"Paul M.","family":"Coates","sequence":"additional","affiliation":[]},{"given":"Jean A.","family":"Cortner","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,6,5]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370040206"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.82.2.495"},{"key":"e_1_2_1_4_1","first-page":"385","article-title":"Plasma levels of apolipoprotein A1 and apolipoprotein B in human atherosclerosis","volume":"4","author":"Avogaro P","year":"1978","journal-title":"Artery"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.9.3.326"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.12.10.1176"},{"key":"e_1_2_1_7_1","first-page":"104","article-title":"Simultaneous effects of the apolipoprotein E polymorphism on apolipoprotein E, apolipoprotein B, and cholesterol metabolism","volume":"42","author":"Boerwinkle E","year":"1988","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199011083231901"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.1980.tb00318.x"},{"issue":"5","key":"e_1_2_1_10_1","first-page":"1038","article-title":"Pedigree and sib\u2010pair linkage analysis suggests that the apoB gene is not the major gene influencing plasma apoB levels","volume":"50","author":"Coresh J","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)81595-1"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/gepi.1370060505"},{"key":"e_1_2_1_13_1","unstructured":"ElstonRC Bailey\u2010WilsonJ BonneyG KeatsB WilsonAF(1986):A Package of Computer Programs to Perform Statistical Analysis for Genetic Epidemiology. 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