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Glial reactivity was assessed through the use of a battery of antibodies which recognise four different proteins\u2014glial fibrillary protein (GFAP) and three other proteins designated repectively MA1, 4D6 and 4H11. Retinal astrocytes did not exhibit any changes in normally expressed GFAP or MA1. By contrast, the expression of GFAP and MA1 in M\u00fcller cells increased 14 days following section of the optic nerve and\/or intravitreal insertions of a glass capillary. Three days postoperatively, the expression of GFAP, but not MA1, had already increased significantly in M\u00fcller cells. 4D6 and 4H11 proteins were not expressed in astrocytes. In M\u00fcller cells, the levels of these proteins increased significantly following combined optic nerve section and intraocular insertion of a glass capillary. Thus, a mechanical disturbance of the intraocular environment constitutes a more effective stimulus in increasing the expression of some M\u00fcllerian proteins than damage to the axons of retinal ganglion cells. Such changes have important implications for various ocular treatments that involve intraocular administration of drugs, as well as for the survival\/regeneration potential of retinal ganglion cells undergoing Wallerian degeneration. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/glia.440150203","type":"journal-article","created":{"date-parts":[[2005,5,12]],"date-time":"2005-05-12T18:22:02Z","timestamp":1115922122000},"page":"105-118","source":"Crossref","is-referenced-by-count":24,"title":["Glial reactivity in the retina of adult rats"],"prefix":"10.1002","volume":"15","author":[{"given":"Krystel R.","family":"Huxlin","sequence":"first","affiliation":[]},{"given":"Zofia","family":"Dreher","sequence":"additional","affiliation":[]},{"given":"Mark","family":"Schulz","sequence":"additional","affiliation":[]},{"given":"Bogdan","family":"Dreher","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,12]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(91)90233-P"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(79)90106-4"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(85)80105-1"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1994.tb00840.x"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713689008999613"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90212-7"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0012-1606(92)90162-A"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/1350-9462(94)90015-9"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4886(80)90110-7"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440140105"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.901950210"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903500107"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903230106"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0952523800001449"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.440030609"},{"key":"e_1_2_1_17_1","first-page":"1231","article-title":"M\u00fcller cell expression of glial fibrillary acidic protein after genetic and experimental photoreceptor degeneration in the rat retina","volume":"25","author":"Eisenfeld A.","year":"1984","journal-title":"Invest. 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