{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T21:38:36Z","timestamp":1761946716363,"version":"3.30.0"},"reference-count":31,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":11445,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,5]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Focal hepatocellular hyperplasia and focal mixed (hepatocytes and sinusoidal cells) hyperplasia are early histological alterations indicative of vinyl monomer exposure. To evaluate their uses in screening chemical workers, 93 liver biopsy specimens from 78 persons were examined in double-blind duplicative fashion. Forty-eight specimens were from exposed chemical workers, 35 of them having liver biopsy(ies) for hepatic test abnormalities and 13 for nonliver-related reasons. A comparison group consisted of 30 nonchemical workers who had undergone liver biopsy for nonliver related reasons. Twenty-three of the exposed workers (48%) had hepatic lesions consistent with exposure: 17 (35%) of these had focal hepatocytic hyperplasia, while 6 (13%) had focal mixed hyperplasia or more advanced lesions. Only five of the comparison group had like findings: four (13%) had focal hepatocytic hyperplasia; one had focal mixed hyperplasia and sinusoidal dilatation. This individual had persistent hepatic test abnormalities with the focal mixed hyperplasia and a sinusoidal dilatation, and on subsequent biopsy, angiosarcoma (and a history of using hair spray containing vinyl chloride propellant). Ten individuals had 25 multiple biopsies also read double-blindly; 10 had two or more readings of the same biopsy. Duplicate 21 of 23 (91%) and multiple 27 of 28 (96%) biopsy interpretations in the same individual were identical. Only 6% of either duplicate and\/or multiple readings disagreed. Both focal hepatocellular and mixed hyperplasia were always associated with abnormalities in hepatic test results of which indocyanine green clearance was the most sensitive and \u03b3-glutamyl transpeptidase the least specific. Focal hepatocellular hyperplasia is a more common finding and occurs earlier than the focal mixed hyperplasia among vinyl monomer exposed workers. Follow-up for 5 to 7 years yielded no biochemical or histological evidence of spontaneous progression of this lesion in a work environment where vinyl chloride levels were 10 ppm with time-weighted averages of 1 to 2 ppm. Focal mixed hyperplasia is, as noted, a later and less frequent finding among vinyl monomer-exposed workers. Some individuals with this lesion develop hepatic angiosarcoma independent of subsequent vinyl monomer exposure. In screening for chemical liver injury, indocyanine green clearance supplementary to routine tests is recommended with confirmation by liver biopsy.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840040310","type":"journal-article","created":{"date-parts":[[2008,8,22]],"date-time":"2008-08-22T13:28:13Z","timestamp":1219411693000},"page":"413-418","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":38,"title":["Early Hepatic Histologic Alterations Among Chemical (Vinyl Monomer) Workers\u2020"],"prefix":"10.1097","volume":"4","author":[{"given":"Carlo H.","family":"Tamburro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laszlo","family":"Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Popper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.1840040310-BIB1","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1749-6632.1975.tb51102.x","article-title":"Pathology of angiosarcoma of the liver among vinyl chloride-polyvinyl chloride workers","volume":"246","author":"Thomas","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840040310-BIB2","first-page":"196","article-title":"Klinische und laparoskopisehe aspekte der leberschaeden bei chemiearbeitern in der vinylchlorid-polymerisation","volume":"5","author":"Marsteller","year":"1975","journal-title":"Leber Magen Darm"},{"key":"10.1002\/hep.1840040310-BIB3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/j.1749-6632.1975.tb51103.x","article-title":"Morphology of liver damage among polyvinyl chloride production workers. A report on 51 cases","volume":"246","author":"Gedigk","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840040310-BIB4","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/1097-0142(197601)37:1<149::AID-CNCR2820370122>3.0.CO;2-7","article-title":"Chemical and morphologic features of hepatic angiosarcoma in vinyl chloride workers","volume":"37","author":"Makk","year":"1976","journal-title":"Cancer"},{"key":"10.1002\/hep.1840040310-BIB5","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/j.1749-6632.1975.tb51093.x","article-title":"Alterations of liver and spleen among workers exposed to vinyl chloride","volume":"245","author":"Popper","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840040310-BIB6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1056\/NEJM197501022920104","article-title":"Vinyl-chloride induced liver disease. From idiopathic portal hypertension (Banti's syndrome) to angiosarcoma","volume":"292","author":"Thomas","year":"1975","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840040310-BIB7","first-page":"349","article-title":"Development of hepatic angiosarcoma in man, induced by vinyl chloride, thorotrast and arsenic","volume":"92","author":"Popper","year":"1978","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840040310-BIB8","first-page":"1359","volume-title":"Cold Spring Harbor Conferences on Cell Proliferation, Vol 4. Origins of Human Cancer","author":"Popper","year":"1977"},{"key":"10.1002\/hep.1840040310-BIB9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF00432239","article-title":"Die ultrastruktur der leberschaedigung bei der chronischen vinylchloridintoxikation","volume":"373","author":"Schattenberg","year":"1977","journal-title":"Virchows Arch A Pathol Anat"},{"key":"10.1002\/hep.1840040310-BIB10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/00028896309342963","article-title":"Effects of single and repeated exposures of humans and rats to vinyl chloride","volume":"24","author":"Lester","year":"1963","journal-title":"Ind Hyg J"},{"key":"10.1002\/hep.1840040310-BIB11","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/003591577606900426","article-title":"Histopathology of liver lesions associated with exposure to vinyl chloride monomer","volume":"69","author":"Weinbren","year":"1976","journal-title":"Proc Roy Soc Med"},{"key":"10.1002\/hep.1840040310-BIB12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1749-6632.1975.tb51085.x","article-title":"Unusual splenomegalic liver disease as evidenced by peritoneoscopy and guided liver biopsy among polyvinyl chloride production workers","volume":"246","author":"Marsteller","year":"1975","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840040310-BIB13","first-page":"126","article-title":"Health effects of vinyl chloride","volume":"37","author":"Tamburro","year":"1978","journal-title":"Texas Rep Biol Med"},{"key":"10.1002\/hep.1840040310-BIB14","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1080\/00028896109343421","article-title":"The toxicity of vinyl chloride as determined by repeated exposure of laboratory animals","volume":"22","author":"Torkelson","year":"1961","journal-title":"Ind Hyg J"},{"key":"10.1002\/hep.1840040310-BIB15","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1111\/j.1749-6632.1976.tb23144.x","article-title":"Predictive value of carcinogenesis bioassays","volume":"271","author":"Maltoni","year":"1976","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840040310-BIB16","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1186\/BF03547913","article-title":"The pathology of vinyl chloride exposed mice","volume":"17","author":"Holmberg","year":"1976","journal-title":"Acta Vet Scand"},{"key":"10.1002\/hep.1840040310-BIB17","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1080\/15287397909529818","article-title":"Biochemical alterations in livers of rats exposed to vinyl chloride","volume":"5","author":"Du","year":"1979","journal-title":"J Toxicol Environ Health"},{"key":"10.1002\/hep.1840040310-BIB18","first-page":"143","article-title":"One-year time sequence inhalation toxicity study of vinyl chloride in rats. III. Morphological changes in the liver","volume":"13","author":"Feron","year":"1979","journal-title":"Toxicology"},{"key":"10.1002\/hep.1840040310-BIB19","first-page":"83","article-title":"Formation of pre-neoplastic hepatocellular foci by vinyl bromide in newborn rats","volume":"43","author":"Bolt","year":"1979","journal-title":"Toxicology"},{"key":"10.1002\/hep.1840040310-BIB20","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0041-008X(80)90329-4","article-title":"Effects of vinylidene chloride on DNA synthesis and DNA repair in the rat and mouse. A comparison study with dimethylnitrosamine","volume":"52","author":"Reitz","year":"1980","journal-title":"Toxicol Appl Pharmacol"},{"key":"10.1002\/hep.1840040310-BIB21","first-page":"1143","volume-title":"System sciences in health care","volume":"2","author":"Greenberg","year":"1981"},{"issue":"5","key":"10.1002\/hep.1840040310-BIB22","first-page":"353","article-title":"Exposure indices for epidemiological surveillance of carcinogenic agents in an industrial chemical environment","volume":"23","author":"Greenberg","year":"1981","journal-title":"J Occup Med"},{"key":"10.1002\/hep.1840040310-BIB23","first-page":"319","volume-title":"Developments in toxicology and environmental science","volume":"8","author":"Tamburro","year":"1980"},{"key":"10.1002\/hep.1840040310-BIB24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0046-8177(81)80242-0","article-title":"Nodular transformation (nodular \u201cregenerative\u201d hyperplasia) of the liver","volume":"12","author":"Stromeyer","year":"1981","journal-title":"Human Pathol"},{"key":"10.1002\/hep.1840040310-BIB25","unstructured":"Tamburro CH, Greenberg R, Newby LG, et al. Final project report: implementation and assessment of a demonstration cancer control detection and prevention program in a cohort of industrial workers, 1978, NCI NO1 CN-55212."},{"key":"10.1002\/hep.1840040310-BIB26","first-page":"60","volume-title":"Guidelines for detection of hepatotoxicity due to drugs and chemicals","author":"Tamburro","year":"1979"},{"key":"10.1002\/hep.1840040310-BIB27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1289\/ehp.8141117","article-title":"Effectiveness of federally-required medical laboratory screening in the detection of chemical liver injury","volume":"41","author":"Tamburro","year":"1981","journal-title":"Environmental Perspectives"},{"key":"10.1002\/hep.1840040310-BIB28","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/S0025-7125(16)31687-X","article-title":"Chemical hepatitis, pathogenesis, detection and management","volume":"63","author":"Tamburro","year":"1979","journal-title":"Med Clin N Amer"},{"key":"10.1002\/hep.1840040310-BIB29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF00539093","article-title":"So-called vinyl chloride disease. Is it an occupational systemic sclerosis?","volume":"32","author":"Lange","year":"1974","journal-title":"Int Arch Arbeitsmed"},{"key":"10.1002\/hep.1840040310-BIB30","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/BF02773628","article-title":"Electron microscopic observation of the liver in portal hypertension following chronic exposure to vinyl monomer","volume":"12","author":"Kurokawa","year":"1977","journal-title":"Gastroenterol Jpn"},{"key":"10.1002\/hep.1840040310-BIB31","first-page":"2311","article-title":"Chronischtoxische leberschaeden bei arbeitern in der PVC-production","volume":"98","author":"Marsteller","year":"1973","journal-title":"Dtsch Med Wochenschr"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840040310","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198405000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:00:49Z","timestamp":1733050849000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198405000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840040310","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1984,5]]}}}