{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T11:55:06Z","timestamp":1763726106049,"version":"3.30.0"},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10776,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1986,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The clinical, laboratory and histological features of 47 patients with what is defined as late onset hepatic failure are reviewed. Twenty\u2013five of the patients werefemale and 22 male with a median age of 45 years. Hepatic dysfunction was severe as evidenced by the prolongation of prothrombin time (median = 32 sec, range = 17 to 120 sec). In only four cases was a viral etiology proven (2 hepatitis B, 2 hepatitis A) although the similarity of the clinical features to patients with fulminant viral hepatitis\u2014apart from the longer period of illness prior to the onset of encephalopathy (median = 9 weeks, range = 8 to 24 weeks)\u2014made non\u2013A, non\u2013B infection a possibility in the remainder. There were also similarities to chronic active hepatitis with low titer antibodies to smooth muscle or antinuclear factor in 17% and elevation of the serum IgG in 49%. Liver biopsy in 5 of 8survivors more than 1 year after initial presentation showed chronic active hepatitis in three. Lobular inflammatory infiltrate, bridging necrosis and multilobular collapse were the features of the acute stage of illness in both the survivors and fatal cases. The patients given corticosteroids did not have a statistically significant improvement in survival, and overall mortality for the series was 81%. Hepatic transplantation, successfully performed in one patient, would appear to offer the best chance of survival for the majority of these patients.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840060222","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T19:36:51Z","timestamp":1172950611000},"page":"288-294","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":156,"title":["Late Onset Hepatic Failure: Clinical, Serological and Histological Features"],"prefix":"10.1097","volume":"6","author":[{"given":"Alexander E.S.","family":"Gimson","sequence":"first","affiliation":[]},{"given":"John","family":"O'Grady","sequence":"additional","affiliation":[]},{"given":"Roland J.","family":"Ede","sequence":"additional","affiliation":[]},{"given":"Bernard","family":"Portmann","sequence":"additional","affiliation":[]},{"given":"Roger","family":"Williams","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"10.1002\/hep.1840060222-BIB1","first-page":"292","volume-title":"Progress in liver disease","volume":"3","author":"Trey","year":"1970","unstructured":". The management of fulminant hepatic failure. In: , eds. Progress in liver disease, Vol 3. New York: Grune & Stratton, 1970: 292\u2013298."},{"key":"10.1002\/hep.1840060222-BIB2","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1136\/gut.24.12.1194","volume":"24","author":"Gimson","year":"1983","journal-title":"Gut"},{"key":"10.1002\/hep.1840060222-BIB3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1136\/gut.21.1.72","volume":"21","author":"Mathiesen","year":"1980","journal-title":"Gut"},{"key":"10.1002\/hep.1840060222-BIB4","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0016-5085(76)80334-4","volume":"70","author":"Conn","year":"1976","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840060222-BIB5","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/j.0954-6820.1949.tb05596.x","volume":"234","author":"Bjorneboe","year":"1949","journal-title":"Acta Med Scand (Suppl)"},{"key":"10.1002\/hep.1840060222-BIB6","first-page":"85","volume":"266","author":"Tisdale","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840060222-BIB7","first-page":"425","volume-title":"Viral hepatitis: a contemporary assessment of etiology, epidemiology, pathogenesis and prevention","author":"Redeker","year":"1978","unstructured":"Advances in clinical aspects of acute and chronic liver disease of viral origin. In: , , eds. Viral hepatitis: a contemporary assessment of etiology, epidemiology, pathogenesis and prevention. Philadelphia: The Franklin Institute Press, 1978: 425\u2013429."},{"key":"10.1002\/hep.1840060222-BIB8","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1056\/NEJM197011122832001","volume":"283","author":"Boyer","year":"1970","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.1840060222-BIB9","first-page":"79","volume-title":"Viral hepatitis: a contemporary assessment of etiology, epidemiology, pathogenesis and prevention","author":"Peters","year":"1978","unstructured":", , et al. Protracted viral hepatitis with impaired regeneration. In: , , eds. Viral hepatitis: a contemporary assessment of etiology, epidemiology, pathogenesis and prevention. Philadelphia: The Franklin Institute Press, 1978: 79\u201384."},{"key":"10.1002\/hep.1840060222-BIB10","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0016-5085(19)31757-3","volume":"73","author":"Horney","year":"1977","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840060222-BIB11","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1007\/BF01072881","volume":"23","author":"Spitz","year":"1978","journal-title":"Dig Dis"},{"key":"10.1002\/hep.1840060222-BIB12","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0046-8177(72)80072-8","volume":"3","author":"Baggenstoss","year":"1972","journal-title":"Hum Pathol"},{"key":"10.1002\/hep.1840060222-BIB13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/0016-5085(81)90707-1","volume":"80","author":"Ware","year":"1981","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840060222-BIB14","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1136\/gut.20.7.620","volume":"20","author":"E.A.S.L. 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A)"},{"key":"10.1002\/hep.1840060222-BIB19","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/hep.1840040708","volume":"4","author":"Williams","year":"1984","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840060222-BIB20","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1136\/bmj.290.6461.49","volume":"290","author":"Williams","year":"1985","journal-title":"Br Med J"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840060222","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-198603000-00021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:13:34Z","timestamp":1733051614000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-198603000-00021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,3]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1986]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840060222","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1986,3]]}}}