{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T05:46:49Z","timestamp":1773035209651,"version":"3.50.1"},"reference-count":24,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":10411,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1987,3]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Hepatobiliary and renal elimination of cysteinyl leu-kotrienes were investigated in a mutant rat strain with a hereditary defect in the hepatobiliary excretion of conjugated bilirubin, dibromosulfophthalein and oua-bain. After intravenous injection of [<jats:sup>3<\/jats:sup>H]leukotriene C<jats:sub>4<\/jats:sub>, the initial half-life of radioactivity circulating in blood was 79 \u00b1 15 sec (S.D.) in transport mutant rats as compared to 31 \u00b1 6 sec (S.D.) in normal Wistar rats. The intrahepatic leukotriene radioactivity was increased 5-fold after 1 hr in mutant rats, while the biliary elimination of [<jats:sup>3<\/jats:sup>H]Ieukotrienes was reduced to 1.8% of control. In normal rats, 77 \u00b1 7% (S.D.) of the administered leukotriene radioactivity were recovered in bile within 1 hr. The total recovery of radioactivity from bile, urine, liver, intestine, stomach, kidneys, muscular system and blood 1 hr after intravenous [<jats:sup>3<\/jats:sup>H]leukotriene C<jats:sub>4<\/jats:sub> was 89 \u00b1 6% (S.D.) in normal rats and 46 \u00b1 4% (S.D.) in transport mutants. Enterohepatic circulation was studied after intraduodenal administration of <jats:italic toggle=\"yes\">N<\/jats:italic>-acetyl-[<jats:sup>3<\/jats:sup>H]leukotriene E<jats:sub>4<\/jats:sub>, a major cysteinyl leukotriene metabolite in rat bile. In transport mutants, hepatobiliary elimination of the intestinally absorbed [<jats:sup>3<\/jats:sup>H]leukotriene was reduced to 5%, whereas urinary excretion was not significantly affected. [<jats:sup>3<\/jats:sup>H]Leukotriene metabolites in bile, liver and urine were separated by reversed-phase high-performance liquid chromatography. The proportion of <jats:italic toggle=\"yes\">N<\/jats:italic>-acetyl-[<jats:sup>3<\/jats:sup>H]leukotriene E<jats:sub>4<\/jats:sub> relative to polar leukotriene metabolites was higher in the bile of transport mutants as compared to control Wistar rats when analyzed within 30 to 60 min after intravenous injection of [<jats:sup>3<\/jats:sup>H]leukotriene C<jats:sub>4<\/jats:sub>. Our results indicate that the cysteinyl leukotrienes are physiological substrates of the can-alicular transport system for organic anions such as dibromosulfophthalein. The transport mutant rats serve to characterize the hepatobiliary excretion system for cysteinyl leukotrienes.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840070204","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T20:12:02Z","timestamp":1172952722000},"page":"224-228","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":117,"title":["Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion"],"prefix":"10.1097","volume":"7","author":[{"given":"Michael","family":"Huber","sequence":"first","affiliation":[]},{"given":"Albrecht","family":"Guhlmann","sequence":"additional","affiliation":[]},{"given":"Peter L. 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Membrane transport of amphiphilic compounds by hepatocytes. In: , , eds. Receptor-mediated uptake in the liver. 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