{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T19:35:43Z","timestamp":1760297743919,"version":"3.37.0"},"reference-count":22,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":9162,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,8]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>The distribution of several extracellular matrix components in the liver of patients with acute viral hepatitis was studied by light and electron microscopy using indirect immunoperoxidase methods.<\/jats:p>\n            <jats:p>Light microscopy revealed type III and type V collagen and fibronectin in the portal tracts and the area of focal necrosis, showing cell infiltration. Type III and type V collagen were more strongly stained in the periphery of focal necrosis. Type IV collagen was seen around the vessels and hepatocytes near the focal necrosis. Electron microscopy showed many transitional Ito cells in the area of focal necrosis and fibroblasts were observed in the portal tracts, showing collagen fiber deposition. Numerous collagen fibrils were observed around fibroblasts, Ito cells and hepatocytes. Using immunoelectron microscopy, type III and type IV collagen and fibronectin were observed in the rough endoplasmic reticulum of Ito cells and hepatocytes localized near the area of focal necrosis or fiber deposition. In addition, type IV collagen was seen in the rough endoplasmic reticulum of endothelial cells forming capillary vessels.<\/jats:p>\n            <jats:p>These results suggest that several extracellular matrix components such as types III, IV and V collagen and fibronectin, produced by Ito cells, hepatocytes or endothelial cells, play important roles in the healing of liver damage in acute viral hepatitis. (Hepatology 1990; 12:249-256).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840120211","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:35:38Z","timestamp":1172964938000},"page":"249-256","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":24,"title":["Immunohistochemistry of the Hepatic Extracellular Matrix in Acute Viral Hepatitis"],"prefix":"10.1097","volume":"12","author":[{"given":"Sadataka","family":"Inuzuka","sequence":"first","affiliation":[]},{"given":"Takato","family":"Ueno","sequence":"additional","affiliation":[]},{"given":"Takuji","family":"Torimura","sequence":"additional","affiliation":[]},{"given":"Michio","family":"Sata","sequence":"additional","affiliation":[]},{"given":"Hirohiko","family":"Abe","sequence":"additional","affiliation":[]},{"given":"Kyuichi","family":"Tanikawa","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"10.1002\/hep.1840120211-BIB1","first-page":"166","volume":"53","author":"Hernandez","year":"1985","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840120211-BIB2","first-page":"509","volume":"59","author":"Takahara","year":"1988","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840120211-BIB3","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.2957\/kanzo.28.1589","volume":"28","author":"Ueno","year":"1987","journal-title":"Acta Hepatol Jpn"},{"key":"10.1002\/hep.1840120211-BIB4","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1007\/BF01724682","volume":"59","author":"Rauterberg","year":"1981","journal-title":"Klin Wochenschr"},{"key":"10.1002\/hep.1840120211-BIB5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hep.1840060212","volume":"6","author":"Clement","year":"1986","journal-title":"Hepatology"},{"key":"10.1002\/hep.1840120211-BIB6","doi-asserted-by":"crossref","first-page":"8681","DOI":"10.1073\/pnas.82.24.8681","volume":"82","author":"Friedman","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.1840120211-BIB7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3109\/00365528809095908","volume":"23","author":"Bissell","year":"1988","journal-title":"Scand J Gastroenterol"},{"key":"10.1002\/hep.1840120211-BIB8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/0005-2795(75)90106-3","volume":"405","author":"Bailey","year":"1975","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/hep.1840120211-BIB9","first-page":"205","volume":"144","author":"Gay","year":"1978","journal-title":"Acta Chir Scand"},{"key":"10.1002\/hep.1840120211-BIB10","first-page":"551","volume":"19","author":"Ueno","year":"1986","journal-title":"J Clin Electron Microsc"},{"key":"10.1002\/hep.1840120211-BIB11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.2957\/kanzo.29.1023","volume":"29","author":"Inuzuka","year":"1988","journal-title":"Acta Hepatol Jpn"},{"key":"10.1002\/hep.1840120211-BIB12","first-page":"556","volume":"20","author":"Inuzuka","year":"1987","journal-title":"J Clin Electron Microsc"},{"key":"10.1002\/hep.1840120211-BIB13","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/BF00446442","volume":"263","author":"Zeitz","year":"1978","journal-title":"Arch Dermatol Res"},{"key":"10.1002\/hep.1840120211-BIB14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1749-6632.1978.tb16794.x","volume":"312","author":"Matsuda","year":"1978","journal-title":"Ann NY Acad Sci"},{"key":"10.1002\/hep.1840120211-BIB15","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1083\/jcb.88.3.473","volume":"88","author":"Kleinman","year":"1981","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840120211-BIB16","first-page":"367","volume":"111","author":"Martin","year":"1983","journal-title":"Am J Pathol"},{"key":"10.1002\/hep.1840120211-BIB17","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1083\/jcb.92.2.343","volume":"92","author":"Hernandez","year":"1982","journal-title":"J Cell Biol"},{"key":"10.1002\/hep.1840120211-BIB18","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1177\/00220345850640010501","volume":"64","author":"Kurita","year":"1985","journal-title":"J Dent Res"},{"key":"10.1002\/hep.1840120211-BIB19","first-page":"658","volume":"21","author":"Inuzuka","year":"1988","journal-title":"J Clin Electron Microsc"},{"key":"10.1002\/hep.1840120211-BIB20","first-page":"57","volume":"51","author":"Hernandez","year":"1984","journal-title":"Lab Invest"},{"key":"10.1002\/hep.1840120211-BIB21","first-page":"3","volume-title":"Fine structural features and roles of fat-storing cell and basement membrane in hepatic fibrosis","author":"Tanikawa","year":"1985","unstructured":". Fine structural features and roles of fat-storing cell and basement membrane in hepatic fibrosis. In: , eds. Pathobiology of hepatic fibrosis. New York: Elsevier Science Publishers, 1985: 3\u201311."},{"key":"10.1002\/hep.1840120211-BIB22","first-page":"453","volume-title":"Basement membranes","author":"Tanikawa","year":"1985","unstructured":", . Basement membrane in the liver and its changes. In: ed. Basement membranes. 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