{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T19:18:05Z","timestamp":1775243885399,"version":"3.50.1"},"reference-count":19,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8828,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>We assessed the prevalence and clinical significance of antibodies to hepatitis C virus among a cohort of 148 patients with chronic hepatitis B virus infection. Sixteen patients (11%) had anti-hepatitis C virus detectable by enzyme-linked immunoassay. The results from eight of these patients were positive by recombinant immunoblot assay. The results of recombinant immunoblot assay testing were not consistent; therefore the analysis of the patients\u2019 data was based on anti-hepatitis C virus enzyme-linked immunoassay results. Patients with chronic hepatitis B with anti-hepatitis C virus were more likely to be cirrhotic (44% vs. 21%) and to have decompensated liver disease (24% vs. 6%). Hepatitis B virus replication appeared to be suppressed in patients with both infections as measured by hepatitis B virus\u2014associated DNA polymerase activity (mean = 2,055 vs. 2,555 cpm). Human immunodeficiency virus infection was more common in the anti-hepatitis C virus positive group (36% vs. 11%). Thus hepatitis C virus appears to suppress hepatitis B virus replication and to cause more severe liver disease in patients with chronic hepatitis B infection. (HEPATOLOGY 1991;14:64-67.)<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840140111","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T23:59:55Z","timestamp":1172966395000},"page":"64-67","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":184,"title":["The significance of antibody to hepatitis C virus in patients with chronic hepatitis B"],"prefix":"10.1097","volume":"14","author":[{"given":"Tse-Ling","family":"Fong","sequence":"first","affiliation":[]},{"given":"Adrian M.","family":"Di Bisceglie","sequence":"additional","affiliation":[]},{"given":"Jeanne G.","family":"Waggoner","sequence":"additional","affiliation":[]},{"given":"Steven M.","family":"Banks","sequence":"additional","affiliation":[]},{"given":"Jay H.","family":"Hoofnagle","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"10.1002\/hep.1840140111-BIB1","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0016-5085(83)90336-0","volume":"85","author":"Dienstag","year":"1983","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840140111-BIB2","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1001\/jama.1989.03430090063034","volume":"262","author":"Alter","year":"1989","journal-title":"JAMA"},{"key":"10.1002\/hep.1840140111-BIB3","doi-asserted-by":"crossref","first-page":"544","DOI":"10.7326\/0003-4819-112-7-544","volume":"112","author":"Everhart","year":"1990","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840140111-BIB4","doi-asserted-by":"crossref","first-page":"733","DOI":"10.7326\/0003-4819-101-6-733","volume":"101","author":"Stevens","year":"1984","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840140111-BIB5","doi-asserted-by":"crossref","first-page":"488","DOI":"10.7326\/0003-4819-104-4-488","volume":"104","author":"Koziol","year":"1986","journal-title":"Ann Intern Med"},{"key":"10.1002\/hep.1840140111-BIB6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1126\/science.2523562","volume":"244","author":"Choo","year":"1989","journal-title":"Science"},{"key":"10.1002\/hep.1840140111-BIB7","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1126\/science.2496467","volume":"244","author":"Kuo","year":"1989","journal-title":"Science"},{"key":"10.1002\/hep.1840140111-BIB8","author":"Alter","year":"1989","unstructured":", , , , , . Detection of antibody to hepatitis C virus in prospectively followed transfusion recipients with acute and chronic non-A, non-B hepatitis. N Engl J Med 1989; 1494\u20131500."},{"key":"10.1002\/hep.1840140111-BIB9","first-page":"957","volume-title":"Diagnostic procedures for viral, rickettsial and chlamydial infections","author":"Purcell","year":"1989","unstructured":", , . Hepatitis viruses. In: , eds. Diagnostic procedures for viral, rickettsial and chlamydial infections. 6th ed. Washington DC: American Public Health Association, 1989; 957\u20131065."},{"key":"10.1002\/hep.1840140111-BIB10","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","volume":"1","author":"Knodell","year":"1981","journal-title":"HEPATOLOGY"},{"key":"10.1002\/hep.1840140111-BIB11","first-page":"264","volume":"17","author":"Good","year":"1955","journal-title":"J R Statist Soc"},{"key":"10.1002\/hep.1840140111-BIB12","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/0016-5085(89)90405-8","volume":"97","author":"Martin","year":"1989","journal-title":"Gastroenterology"},{"key":"10.1002\/hep.1840140111-BIB13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jama.1990.03440010047028","volume":"263","author":"Stevens","year":"1990","journal-title":"JAMA"},{"key":"10.1002\/hep.1840140111-BIB14","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(89)90853-2","volume":"2","author":"Fattovich","year":"1989","journal-title":"Lancet"},{"key":"10.1002\/hep.1840140111-BIB15","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/0140-6736(90)90870-B","volume":"335","author":"McFarlane","year":"1990","journal-title":"Lancet"},{"key":"10.1002\/hep.1840140111-BIB16","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1016\/0140-6736(90)91055-F","volume":"335","author":"Eberling","year":"1990","journal-title":"Lancet"},{"key":"10.1002\/hep.1840140111-BIB17","first-page":"1005","volume":"85","author":"Tsianos","year":"1990","journal-title":"Am J Gastroenterology"},{"key":"10.1002\/hep.1840140111-BIB18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0140-6736(90)90134-Q","volume":"335","author":"Weiner","year":"1990","journal-title":"Lancet"},{"key":"10.1002\/hep.1840140111-BIB19","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/978-1-4684-7041-3_5","volume-title":"Current perspectives in hepatology","author":"Hoofnagle","year":"1989","unstructured":"Delta hepatitis and the hepatitis delta virus. In: , eds. Current perspectives in hepatology. New York: Plenum Publishing Corp., 1989; 47\u201362."}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.1840140111","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199107000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T11:00:11Z","timestamp":1733050811000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199107000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,7]]},"references-count":19,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.1840140111","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[1991,7]]}}}