{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T16:23:45Z","timestamp":1762100625157,"version":"3.30.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":8005,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1993,10]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Frequent allele loss from chromosome 16q was recently described for human tumors of the breast, prostate gland and liver, indicating the possible presence of a tumor-suppressor gene on that chromosome arm. In this study, the chromosome 16 allele status of 38 hepatocellular carcinomas in Chinese patients was determined with restriction-fragmentlength polymorphism analysis. Tumor-specific allele loss was detected in 14(74%) of 19 patients informative for 16p markers and in 22 (85%) of 26 patients informative for 16p markers. Quantitative densitometric analysis revealed reduction to hemizygosity of the E-cadherin cell adhesion gene (localized to 16q22.1) in 18 (64%) of the 28 patients for whom quantitative data were available. Reduced expression of E-cadherin has been associated with invasion and metastasis in several human cell lines and primary tumors, and our results suggest that one mechanism of reduced E-cadherin expression is the loss of one copy of the E-cadherin gene. (HEPATOLOGY 1993;18:757-762).<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.1840180402","type":"journal-article","created":{"date-parts":[[2007,3,4]],"date-time":"2007-03-04T02:07:39Z","timestamp":1172974059000},"page":"757-762","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":52,"title":["Deletion of the E-cadherin gene in hepatitis B virus-positive chinese hepatocellular carcinomas"],"prefix":"10.1097","volume":"18","author":[{"given":"Betty L.","family":"Slagle","sequence":"first","affiliation":[]},{"given":"Yi-Zhong","family":"Zhou","sequence":"additional","affiliation":[]},{"given":"Walter","family":"Birchmeier","sequence":"additional","affiliation":[]},{"given":"Kathleen A.","family":"Scorsone","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"10.1002\/hep.1840180402-BIB1","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1007\/978-1-4613-0705-1_29","volume-title":"Viral infections of humans","author":"Melnick","year":"1989","unstructured":"Hepatocellular carcinoma caused by hepatitis B virus. 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