{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T18:14:15Z","timestamp":1773771255699,"version":"3.50.1"},"reference-count":15,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":2769,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>\n                                 <jats:bold>Transient elastography [FibroScan (FS)] is a rapid, noninvasive, and reproducible method for measuring liver stiffness, which correlates with the degree of liver fibrosis in patients with chronic hepatitis. Whether FS is useful in the detection of preexisting liver fibrosis\/cirrhosis in patients presenting with acute liver damage is unclear. Patients with acute liver damage of different etiologies were analyzed. Liver stiffness was measured during the acute phase of the liver damage and followed up to the end of the acute phase. A total of 20 patients were included in the study. In 15 of the 20 patients, initial liver stiffness values measured by FS during the acute phase of the liver damage were suggestive of liver cirrhosis. However, none of these 15 patients showed any signs of liver cirrhosis in the physical examination, ultrasound examination, or liver histology [performed in 11 of 15 (73%) patients]. A significant difference was observed in the initial bilirubin levels (5.8 \u00b1 6.5 mg\/dL versus 15.7 \u00b1 11.8 mg\/dL;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.042) and age (32.4 \u00b1 17.5 years versus 49.7 \u00b1 15.8 years;<\/jats:bold>\n                                 <jats:bold>\n                                    P\n                                 <\/jats:bold>\n                                 <jats:bold>= 0.042) between patients with liver stiffness below or above 12.5 kPa. Six patients with initially high liver stiffness were followed up to abatement of the acute hepatitic phase; in all of them, liver stiffness values decreased to values below the cutoff value for liver cirrhosis.<\/jats:bold>\n                                 <jats:bold>\n                                    Conclusion:\n                                 <\/jats:bold>\n                                 <jats:bold>Transient elastography frequently yields pathologically high values in patients with acute liver damage and is unsuitable for detecting cirrhosis\/fibrosis in these patients. (Hepatology 2007.)<\/jats:bold>\n                              <\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.22056","type":"journal-article","created":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T04:16:24Z","timestamp":1198210584000},"page":"592-595","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":420,"title":["Transient elastography is unreliable for detection of cirrhosis in patients with acute liver damage"],"prefix":"10.1097","volume":"47","author":[{"given":"Abdurrahman","family":"Sagir","sequence":"first","affiliation":[]},{"given":"Andreas","family":"Erhardt","sequence":"additional","affiliation":[]},{"given":"Marcus","family":"Schmitt","sequence":"additional","affiliation":[]},{"given":"Dieter","family":"H\u00e4ussinger","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"R1-28-20241201","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1056\/NEJM200102153440706","article-title":"Liver biopsy.","volume":"344","author":"Bravo","year":"2001","journal-title":"N Engl J Med"},{"key":"R2-28-20241201","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1001\/archinte.1979.03630430043014","article-title":"Sampling variability on percutaneous liver biopsy.","volume":"139","author":"Abdi","year":"1979","journal-title":"Arch Intern Med"},{"key":"R3-28-20241201","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","article-title":"Sampling variability of liver fibrosis in chronic hepatitis C.","volume":"38","author":"Bedossa","year":"2003","journal-title":"HEPATOLOGY"},{"key":"R4-28-20241201","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1053\/jhep.2000.16602","article-title":"Degos F, for the Group of Epidemiology of the French Association for the Study of the Liver (AFEF). Practices of liver biopsy in France: results of a prospective nationwide survey.","volume":"32","author":"Cadranel","year":"2000","journal-title":"HEPATOLOGY"},{"key":"R5-28-20241201","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0140-6736(86)90883-4","article-title":"Sampling variability and its influence on the diagnostic yield of percutaneous needle biopsy of the liver.","volume":"1","author":"Maharaj","year":"1986","journal-title":"Lancet"},{"key":"R6-28-20241201","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1111\/j.1572-0241.2002.06038.x","article-title":"Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection.","volume":"97","author":"Regev","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"R7-28-20241201","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.ultrasmedbio.2003.07.001","article-title":"Transient elastography: a new noninvasive method for assessment of hepatic fibrosis.","volume":"29","author":"Sandrin","year":"2003","journal-title":"Ultrasound Med Biol"},{"key":"R8-28-20241201","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1097\/00042737-200604000-00015","article-title":"Prevalence and factors associated with failure of liver stiffness measurement using FibroScan in a prospective study of 2114 examinations.","volume":"18","author":"Foucher","year":"2006","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"R9-28-20241201","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1055\/s-2006-957180","article-title":"Transient elastography for diagnosing liver cirrhosis. in German.","volume":"131","author":"Erhardt","year":"2006","journal-title":"Dtsch Med Wochenschr"},{"key":"R10-28-20241201","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1053\/j.gastro.2004.11.018","article-title":"Prospective comparison of transient elastography, Fibrotest, APRI, and liver biopsy for the assessment of fibrosis in chronic hepatitis C.","volume":"128","author":"Castera","year":"2005","journal-title":"Gastroenterology"},{"key":"R11-28-20241201","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1136\/gut.2005.069153","article-title":"Diagnosis of cirrhosis by transient elastography (FibroScan): a prospective study.","volume":"55","author":"Foucher","year":"2006","journal-title":"Gut"},{"key":"R12-28-20241201","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1002\/hep.21420","article-title":"Accuracy of liver stiffness measurement for the diagnosis of cirrhosis in patients with chronic liver diseases.","volume":"44","author":"GanneCarrie","year":"2006","journal-title":"HEPATOLOGY"},{"key":"R13-28-20241201","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1365-2893.2006.00811.x","article-title":"Transient elastography: a new surrogate marker of liver fibrosis influenced by major changes of transaminases.","volume":"14","author":"Coco","year":"2007","journal-title":"J Viral Hepat"},{"key":"R14-28-20241201","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1148\/radiology.172.2.2526349","article-title":"Cirrhosis: diagnosis with sonographic study of the liver surface.","volume":"172","author":"Di Lelio","year":"1989","journal-title":"Radiology"},{"key":"R15-28-20241201","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1097\/01.qai.0000194238.15831.c7","article-title":"Diagnosis of hepatic fibrosis and cirrhosis by transient elastography in HIVhepatitis C viruscoinfected patients.","volume":"41","author":"de Ledinghen","year":"2006","journal-title":"J Acquir Immune Defic Syndr"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.22056","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-200802000-00028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T13:30:06Z","timestamp":1733059806000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-200802000-00028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.22056","relation":{},"ISSN":["0270-9139"],"issn-type":[{"value":"0270-9139","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}