{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:04:39Z","timestamp":1760954679021,"version":"3.37.0"},"reference-count":72,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"2","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6605,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1997,8]]},"DOI":"10.1002\/hep.510260237","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:16:59Z","timestamp":1090970219000},"page":"251-255","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":50,"title":["Gene therapy for chronic viral hepatitis: Ribozymes, antisense oligonucleotides, and dominant negative mutants"],"prefix":"10.1097","volume":"26","author":[{"given":"F","family":"von Weizs\u00e4cker","sequence":"first","affiliation":[]},{"given":"S","family":"Wieland","sequence":"additional","affiliation":[]},{"given":"J","family":"K\u00f6ck","sequence":"additional","affiliation":[]},{"given":"W","family":"Offensperger","sequence":"additional","affiliation":[]},{"given":"S","family":"Offensperger","sequence":"additional","affiliation":[]},{"given":"D","family":"Moradpour","sequence":"additional","affiliation":[]},{"given":"H E","family":"Blum","sequence":"additional","affiliation":[]}],"member":"276","reference":[{"key":"10.1002\/hep.510260237-BIB1|cit1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1056\/NEJM199109053251010","article-title":"Primary hepatocellular carcinoma [Editorial]","volume":"325","author":"Wands","year":"1991","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.510260237-BIB2|cit2","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1056\/NEJM199701303360507","article-title":"The treatment of chronic viral hepatitis","volume":"336","author":"Hoofnagle","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.510260237-BIB3|cit3","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1056\/NEJM199512073332308","article-title":"Muscle mediated gene therapy","volume":"333","author":"Blau","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.510260237-BIB4|cit4","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1056\/NEJM199601043340110","article-title":"DNA vaccines","volume":"334","author":"McDonnell","year":"1996","journal-title":"N Engl J Med"},{"key":"10.1002\/hep.510260237-BIB5|cit5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/1074-7613(95)90085-3","article-title":"Exposing the immunology of naked DNA vaccines","volume":"3","author":"Pardoll","year":"1995","journal-title":"Immunity"},{"key":"10.1002\/hep.510260237-BIB6|cit6","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1038\/nm0896-857","article-title":"Genetic vaccination: The advantages of going naked","volume":"2","author":"Kumar","year":"1996","journal-title":"Nat Med"},{"key":"10.1002\/hep.510260237-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1038\/nm1096-1122","article-title":"DNA-based immunization by in vivo transfection of dendritic cells","volume":"2","author":"Condon","year":"1996","journal-title":"Nat Med"},{"key":"10.1002\/hep.510260237-BIB8|cit8","first-page":"67","article-title":"Selected strategies to augment polynucleotide immunization","volume":"3","author":"Conry","year":"1996","journal-title":"Gene Ther"},{"key":"10.1002\/hep.510260237-BIB9|cit9","doi-asserted-by":"crossref","first-page":"5929","DOI":"10.1128\/JVI.69.10.5929-5934.1995","article-title":"Nucleic acid vaccination primes hepatitis B virus surface antigen specific cytotoxic T lymphocytes in nonresponder mice","volume":"69","author":"Schirmbeck","year":"1995","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB10|cit10","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/hmg\/2.11.1847","article-title":"DNA-based immunization induces continuous secretion of hepatitis B surface antigen and high levels of circulating antibody","volume":"2","author":"Davis","year":"1993","journal-title":"Hum Mol Gen"},{"key":"10.1002\/hep.510260237-BIB11|cit11","doi-asserted-by":"crossref","first-page":"3687","DOI":"10.4049\/jimmunol.156.10.3687","article-title":"DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2 b mice","volume":"156","author":"Kuh\u00f6ber","year":"1996","journal-title":"J Immunol"},{"key":"10.1002\/hep.510260237-BIB12|cit12","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1089\/hum.1995.6.11-1447","article-title":"DNA-mediated immunization in mice induces a potent MHC class I-restricted cytotoxic T lymphocyte response to the hepatitis B envelope protein","volume":"6","author":"Davis","year":"1995","journal-title":"Hum Gene Ther"},{"key":"10.1002\/hep.510260237-BIB13|cit13","doi-asserted-by":"crossref","first-page":"12496","DOI":"10.1073\/pnas.93.22.12496","article-title":"DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state","volume":"93","author":"Mancini","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1002\/hep.510260237-BIB14|cit14","doi-asserted-by":"crossref","first-page":"5859","DOI":"10.1128\/JVI.69.9.5859-5863.1995","article-title":"Immune responses to plasmid DNA encoding the hepatitis C virus core protein","volume":"69","author":"Lagging","year":"1995","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB15|cit15","doi-asserted-by":"crossref","first-page":"5798","DOI":"10.1128\/JVI.69.9.5798-5805.1995","article-title":"DNA based immunization with chimeric vectors for the induction of immune responses against the hepatitis C virus nucleocapsid","volume":"69","author":"Major","year":"1995","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB16|cit16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/hep.510240104","article-title":"Expression and immune response to hepatitis C virus core DNA-based vaccine constructs","volume":"24","author":"Tokushige","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB17|cit17","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.bi.62.070193.001203","article-title":"Human gene therapy","volume":"62","author":"Morgan","year":"1993","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/hep.510260237-BIB18|cit18","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1126\/science.1589762","article-title":"Human gene therapy","volume":"256","author":"Anderson","year":"1992","journal-title":"Science"},{"key":"10.1002\/hep.510260237-BIB19|cit19","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1126\/science.2660259","article-title":"Progress toward human gene therapy","volume":"244","author":"Friedmann","year":"1989","journal-title":"Science"},{"key":"10.1002\/hep.510260237-BIB20|cit20","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0140-6736(92)90606-4","article-title":"Gene therapy for cancer","volume":"339","author":"Gutierrez","year":"1992","journal-title":"Lancet"},{"key":"10.1002\/hep.510260237-BIB21|cit21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/357455a0","article-title":"Human gene therapy comes of age","volume":"357","author":"Miller","year":"1992","journal-title":"Nature"},{"key":"10.1002\/hep.510260237-BIB22|cit22","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1002\/hep.1840180536","article-title":"Hepatic gene therapy: present and future","volume":"18","author":"Ledley","year":"1993","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB23|cit23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1002\/hep.510250238","article-title":"Hepatic drug delivery and gene therapy","volume":"25","author":"Zern","year":"1997","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB24|cit24","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/ng0494-335","article-title":"Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia","volume":"6","author":"Grossman","year":"1994","journal-title":"Nat Genet"},{"key":"10.1002\/hep.510260237-BIB25|cit25","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1038\/nm1195-1148","article-title":"A pilot study of ex vivo gene therapy for homozygous familial hypercholesterolaemia","volume":"1","author":"Grossman","year":"1995","journal-title":"Nat Med"},{"key":"10.1002\/hep.510260237-BIB26|cit26","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1038\/ng0396-266","article-title":"Hepatocytes corrected by gene therapy are selected in vivo in a murine model of hereditary tyrosinaemia type I","volume":"12","author":"Overturf","year":"1996","journal-title":"Nat Genet"},{"key":"10.1002\/hep.510260237-BIB27|cit27","first-page":"51","article-title":"Viral vector systems for gene therapy","volume":"1","author":"Jolly","year":"1994","journal-title":"Cancer Gene Ther"},{"key":"10.1002\/hep.510260237-BIB28|cit28","doi-asserted-by":"crossref","first-page":"6982","DOI":"10.1073\/pnas.86.18.6982","article-title":"Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA","volume":"86","author":"Behr","year":"1989","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.510260237-BIB29|cit29","doi-asserted-by":"crossref","first-page":"7297","DOI":"10.1073\/pnas.92.16.7297","article-title":"A novel versatile vector for gene and oligonucleotide transfer into cells in culture and in vivo: polyethylenimine","volume":"92","author":"Boussif","year":"1995","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1002\/hep.510260237-BIB30|cit30","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1089\/hum.1996.7.16-1947","article-title":"A powerful nonviral vector for in vivo gene transfer into the adult mammalian brain: polyethylenimine","volume":"7","author":"Abdallah","year":"1996","journal-title":"Hum Gene Ther"},{"key":"10.1002\/hep.510260237-BIB31|cit31","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1089\/hum.1995.6.9-1129","article-title":"Nonviral gene therapy: the promise of genes as pharmaceutical products","volume":"6","author":"Ledley","year":"1995","journal-title":"Hum Gene Ther"},{"key":"10.1002\/hep.510260237-BIB32|cit32","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/0277-5379(91)90033-A","article-title":"Rational design of sequence-specific oncogene inhibitors based on antisense and antigene oligonucleotides","volume":"27","author":"Helene","year":"1991","journal-title":"Eur J Cancer"},{"key":"10.1002\/hep.510260237-BIB33|cit33","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0167-4781(90)90031-V","article-title":"Specific regulation of gene expression by antisense, sense and antigene nucleic acids","volume":"1049","author":"Helene","year":"1990","journal-title":"Biochim Biophys Acta"},{"key":"10.1002\/hep.510260237-BIB34|cit34","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/334585a0","article-title":"Simple RNA enzymes with new and highly specific endoribonuclease activities","volume":"334","author":"Haseloff","year":"1988","journal-title":"Nature"},{"key":"10.1002\/hep.510260237-BIB35|cit35","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nm0395-277","article-title":"Ribozymes in gene therapy","volume":"1","author":"Thompson","year":"1995","journal-title":"Nat Med"},{"key":"10.1002\/hep.510260237-BIB36|cit36","first-page":"4505","article-title":"Inhibition of protooncogene expression by antisense oligodeoxynucleotides: biological and therapeutic implications","volume":"51","author":"Calabretta","year":"1991","journal-title":"Cancer Res"},{"key":"10.1002\/hep.510260237-BIB37|cit37","first-page":"65","article-title":"Antisense oligonucleotide technology in the development of cancer therapeutics","volume":"1","author":"Tseng","year":"1994","journal-title":"Cancer Gene Ther"},{"key":"10.1002\/hep.510260237-BIB38|cit38","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1038\/329219a0","article-title":"Functional inactivation of genes by dominant negative mutations","volume":"329","author":"Herschkowitz","year":"1987","journal-title":"Nature"},{"key":"10.1002\/hep.510260237-BIB39|cit39","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/0006-291X(92)92264-X","article-title":"Cleavage of hepatitis B virus RNA by three ribozymes transcribed from a single DNA template","volume":"189","author":"von Weizs\u00e1cker","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/hep.510260237-BIB40|cit40","doi-asserted-by":"crossref","first-page":"4954","DOI":"10.1093\/nar\/23.24.4954","article-title":"Efficient hammerhead ribozyme-mediated cleavage of the structured hepatitis B virus encapsidation signal in vitro and in cell extracts, but not in intact cells","volume":"23","author":"Beck","year":"1995","journal-title":"Nucleic Acids Res"},{"key":"10.1002\/hep.510260237-BIB41|cit41","doi-asserted-by":"crossref","first-page":"8782","DOI":"10.1128\/JVI.70.12.8782-8791.1996","article-title":"Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes","volume":"70","author":"Lieber","year":"1996","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB42|cit42","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1172\/JCI119097","article-title":"Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes","volume":"98","author":"Sakamoto","year":"1996","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.510260237-BIB43|cit43","doi-asserted-by":"crossref","first-page":"9447","DOI":"10.1074\/jbc.271.16.9447","article-title":"Magnesium-mediated conversion of an inactive form of a hammerhead ribozyme to an active complex with its substrate","volume":"271","author":"Orita","year":"1996","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.510260237-BIB44|cit44","first-page":"994","article-title":"A potential therapeutic application of hairpin ribozymes -in vitro and in vivo studies of gene therapy for hepatitis C virus infection","volume":"3","author":"Welch","year":"1996","journal-title":"Gene Ther"},{"key":"10.1002\/hep.510260237-BIB45|cit45","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1128\/MCB.15.1.540","article-title":"Selection of efficient cleavage sites in target RNAs by using a ribozyme library","volume":"15","author":"Lieber","year":"1995","journal-title":"Mol Cell Biol"},{"key":"10.1002\/hep.510260237-BIB46|cit46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/372333a0","article-title":"Gene inhibition using antisense oligodeoxynucleotides","volume":"372","author":"Wagner","year":"1994","journal-title":"Nature"},{"key":"10.1002\/hep.510260237-BIB47|cit47","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1002\/hep.510240634","article-title":"A hitchhiker's guide to antisense and nonantisense biochemical pathways","volume":"24","author":"Branch","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB48|cit48","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/0955-0674(95)80096-4","article-title":"Transgenes and gene suppression: telling us something new?","volume":"7","author":"Dougherty","year":"1995","journal-title":"Curr Opin Cell Biol"},{"key":"10.1002\/hep.510260237-BIB49|cit49","doi-asserted-by":"crossref","first-page":"3021","DOI":"10.1099\/0022-1317-71-12-3021","article-title":"Antisense oligodeoxyribo-nucleotides inhibit the expression of the gene for hepatitis B virus surface antigen","volume":"71","author":"Goodarzi","year":"1990","journal-title":"J Gen Virol"},{"key":"10.1002\/hep.510260237-BIB50|cit50","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1016\/0140-6736(91)92907-J","article-title":"Inhibition of hepatitis B virus by antisense oligodeoxynucleotides","volume":"337","author":"Blum","year":"1991","journal-title":"Lancet"},{"key":"10.1002\/hep.510260237-BIB51|cit51","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1016\/S0021-9258(18)42295-8","article-title":"Specific inhibition of hepatitis B viral gene expression in vitro by targeted antisense oligonucleotides","volume":"267","author":"Wu","year":"1992","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.510260237-BIB52|cit52","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1002\/hep.510230601","article-title":"Inhibition of hepatitis B virus replication by targeted pretreatment of complexed antisense DNA in vitro","volume":"23","author":"Nakazono","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB53|cit53","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.1016\/S0021-9258(17)36775-3","article-title":"Specific inhibition of hepatitis C virus expression by antisense oligodeoxynucleotides. In vitro model for selection of target sequence","volume":"269","author":"Wakita","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1002\/hep.510260237-BIB54|cit54","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1006\/bbrc.1995.2055","article-title":"Inhibition of hepatitis C virus replication by antisense oligonucleotide in culture cells","volume":"212","author":"Mizutani","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1002\/hep.510260237-BIB55|cit55","first-page":"707","article-title":"Specific inhibition of hepatitis C viral gene expression by antisense phosphorothioate oligodeoxynucleotides","volume":"22","author":"Alt","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB56|cit56","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1093\/oxfordjournals.jbchem.a125007","article-title":"Phosphorothioate antisense oligodeoxynucleotides capable of inhibiting hepatitis C virus gene expression: in vitro translation assay","volume":"118","author":"Seki","year":"1995","journal-title":"J Biochem"},{"key":"10.1002\/hep.510260237-BIB57|cit57","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.1128\/JVI.70.8.5203-5212.1996","article-title":"Antisense oligonucleotide inhibition of hepatitis C virus gene expression in transformed hepatocytes","volume":"70","author":"Hanecak","year":"1996","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB58|cit58","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1128\/AAC.40.10.2337","article-title":"In vitro inhibition of hepatitis C virus gene expression by chemically modified antisense oligodeoxynucleotides","volume":"40","author":"Vidalin","year":"1996","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1002\/hep.510260237-BIB59|cit59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1365-2893.1996.tb00076.x","article-title":"In vivo inhibition of hepatitis B viral gene expression by antisense phosphorothioate oligodeoxynucleotides in athymic nude mice","volume":"3","author":"Yao","year":"1996","journal-title":"J Viral Hepatitis"},{"key":"10.1002\/hep.510260237-BIB60|cit60","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1002\/j.1460-2075.1993.tb05767.x","article-title":"In vivo inhibition of duck hepatitis B virus replication and gene expression by phosphorothioate modified antisense oligodeoxynucleotides","volume":"12","author":"Offensperger","year":"1993","journal-title":"Embo J"},{"key":"10.1002\/hep.510260237-BIB61|cit61","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1365-2893.1995.tb00041.x","article-title":"Targeted delivery of antisense DNA in woodchuck hepatitis virus-infected woodchucks","volume":"2","author":"Bartholomew","year":"1995","journal-title":"J Viral Hepatitis"},{"key":"10.1002\/hep.510260237-BIB62|cit62","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1126\/science.2200121","article-title":"Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase","volume":"249","author":"Tuerk","year":"1990","journal-title":"Science"},{"key":"10.1002\/hep.510260237-BIB63|cit63","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/335395a0","article-title":"Intracellular immunization","volume":"325","author":"Baltimore","year":"1988","journal-title":"Nature"},{"key":"10.1002\/hep.510260237-BIB64|cit64","first-page":"667","volume-title":"Viral Hepatitis and Liver Disease","author":"Delaney","year":"1991"},{"key":"10.1002\/hep.510260237-BIB65|cit65","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1006\/viro.1994.1625","article-title":"Characterization of hepatitis B virus core mutants that inhibit viral replication","volume":"205","author":"Scaglioni","year":"1994","journal-title":"Virology"},{"key":"10.1002\/hep.510260237-BIB66|cit66","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1002\/hep.510240202","article-title":"Inhibition of viral replication by genetically engineered mutants of the duck hepatitis B virus core protein","volume":"24","author":"von Weizs\u00e4cker","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB67|cit67","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/hep.510240506","article-title":"Use of dominant negative mutants of the hepadnaviral core protein as antiviral agents","volume":"24","author":"Scaglioni","year":"1996","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB68|cit68","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1128\/JVI.71.1.345-353.1997","article-title":"Posttranscriptional regulation of hepatitis B virus replication by the precore protein","volume":"71","author":"Scaglioni","year":"1997","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB69|cit69","doi-asserted-by":"crossref","first-page":"5845","DOI":"10.1128\/JVI.70.9.5845-5851.1996","article-title":"Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replication","volume":"70","author":"Buckwold","year":"1996","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB70|cit70","doi-asserted-by":"crossref","first-page":"7056","DOI":"10.1128\/JVI.70.10.7056-7061.1996","article-title":"The hepatitis B virus (HBV) precore protein inhibits HBV replication in transgenic mice","volume":"70","author":"Guidotti","year":"1996","journal-title":"J Virol"},{"key":"10.1002\/hep.510260237-BIB71|cit71","first-page":"1316","article-title":"Hepatitis B virus transgenic mice: insights into the virus and the disease","volume":"22","author":"Chisari","year":"1995","journal-title":"Hepatology"},{"key":"10.1002\/hep.510260237-BIB72|cit72","first-page":"S27","article-title":"Animal models of human disease for gene therapy","volume":"98","author":"Wilson","year":"1996","journal-title":"J Clin Invest"}],"container-title":["Hepatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhep.510260237","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/journals.lww.com\/01515467-199708000-00001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T15:24:47Z","timestamp":1738941887000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01515467-199708000-00001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,8]]},"references-count":72,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1997]]}},"URL":"https:\/\/doi.org\/10.1002\/hep.510260237","relation":{},"ISSN":["0270-9139"],"issn-type":[{"type":"print","value":"0270-9139"}],"subject":[],"published":{"date-parts":[[1997,8]]}}}