{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T23:04:56Z","timestamp":1778627096408,"version":"3.51.4"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":6271,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001677","name":"INSERM","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Universit\u00e9 de Rennes I"},{"name":"Association pour la Recherche contre le Cancer (Paris, France)"},{"name":"Health Sciences Council of the Academy of Finland"},{"name":"Sigrid Juselius Foundation, FibroGen Inc. (South San Fransisco, CA)"}],"content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:sec>\n            <jats:title\/>\n            <jats:p>Type XVIII collagen is a recently discovered nonfibrillar collagen associated with basement membranes in mice and expressed at high levels in human liver. We studied the origin, distribution, and RNA levels of type XVIII collagen in normal and fibrotic human livers by <jats:italic toggle=\"yes\">in situ<\/jats:italic> hybridization, immunohistochemistry, and Northern and dot blots and compared procollagen \u03b11(XVIII) RNA levels with those of procollagen \u03b11(IV) and laminin \u03b31, the two major components of liver basement membranes. In normal liver, type XVIII collagen was heavily deposited in perisinusoidal spaces and basement membrane zones. The major source of type XVIII collagen was hepatocytes and, to a lesser extent, endothelial, biliary epithelial, and vascular smooth muscle cells and peripheral nerves. In cirrhosis, type XVIII collagen formed a thick deposit along capillarized sinusoids. Grain counts after <jats:italic toggle=\"yes\">in situ<\/jats:italic> hybridization showed myofibroblasts to increase their expression 13-fold in active and twofold in quiescent fibrosis, whereas hepatocytes increased their expression only twofold in both active and quiescent fibrosis. Activated stellate cells <jats:italic toggle=\"yes\">in vitro<\/jats:italic> expressed type XVIII collagen at high levels. These data indicate that type XVIII collagen is a component of the perisinusoidal space and is associated with basement membrane remodeling. Hepatocytes and activated stellate cells are important sources of type XVIII collagen in normal and fibrotic liver respectively, which suggests tissue-specific regulation of its expression.<\/jats:p>\n          <\/jats:sec>","DOI":"10.1002\/hep.510280115","type":"journal-article","created":{"date-parts":[[2004,7,27]],"date-time":"2004-07-27T23:57:05Z","timestamp":1090972625000},"page":"98-107","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":80,"title":["Collagen XVIII is localized in sinusoids and basement membrane zones and expressed by hepatocytes and activated stellate cells in fibrotic human liver"],"prefix":"10.1097","volume":"28","author":[{"given":"Orlando","family":"Musso","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko","family":"Rehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janna","family":"Saarela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Th\u00e9ret","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jocelyne","family":"Li\u00e9tard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elina","family":"Hintikka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Lotrian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Campion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taina","family":"Pihlajaniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Cl\u00e9ment","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1002\/hep.510280115-BIB1|cit1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.bi.64.070195.002155","article-title":"Collagens: molecular biology, diseases, and potentials for therapy","volume":"64","author":"Prockop","year":"1995","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/hep.510280115-BIB2|cit2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0079-6603(08)60816-8","article-title":"Two new collagen subgroups: membrane-associated collagens and types XV and XVII","volume":"50","author":"Pihlajaniemi","year":"1995","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"10.1002\/hep.510280115-BIB3|cit3","first-page":"327","article-title":"Organization and regulation of collagen genes","volume":"1","author":"Jacenko","year":"1991","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"10.1002\/hep.510280115-BIB4|cit4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1146\/annurev.bi.59.070190.004201","article-title":"The family of collagen genes","volume":"59","author":"Vuorio","year":"1990","journal-title":"Annu Rev Biochem"},{"key":"10.1002\/hep.510280115-BIB5|cit5","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/hep.1840060212","article-title":"Cell types involved in collagen and fibronectin production in normal and fibrotic human liver","volume":"6","author":"Cl\u00e9ment","year":"1986","journal-title":"Hepatology"},{"key":"10.1002\/hep.510280115-BIB6|cit6","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1172\/JCI114886","article-title":"Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo","volume":"86","author":"Maher","year":"1990","journal-title":"J Clin Invest"},{"key":"10.1002\/hep.510280115-BIB7|cit7","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1056\/NEJM199306243282508","article-title":"The cellular basis of hepatic fibrosis. 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