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The hippocampus is an area of particular interest, as it is central to many aspects of the addictive process, including relapse to drug taking. A recently appreciated hippocampal neuroadapation produced by drugs as diverse as opiates and psychostimulants is decreased neurogenesis in the subgranular zone (SGZ). While the role of adult\u2010generated neurons is not clear, their functional integration into hippocampal circuitry raises the possibility that decreased adult SGZ neurogenesis may alter hippocampal function in such a way as to maintain addictive behavior or contribute to relapse. Here, we review the impact of opiates and psychostimulants on the different stages of cell development in the adult brain, as well as the different stages of the addictive process. We discuss how examination of drug\u2010induced alterations of adult neurogenesis advances our understanding of the complex mechanisms by which opiates and psychostimulants affect brain function while also opening avenues for novel ways of assessing the functional role of adult\u2010generated neurons. In addition, we highlight key discrepancies in the field and underscore the necessity to move \u201cbeyond BrdU\u201d\u2013\u2013beyond merely counting new hippocampal cells labeled with the S phase marker bromodeoxyuridine\u2013\u2013so as to probe mechanistic questions about how drug\u2010induced alterations in adult hippocampal neurogenesis occur and what the functional ramifications of alterations in neurogenesis are for addiction. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/hipo.20161","type":"journal-article","created":{"date-parts":[[2006,1,12]],"date-time":"2006-01-12T22:46:31Z","timestamp":1137105991000},"page":"271-286","source":"Crossref","is-referenced-by-count":139,"title":["Opiates, psychostimulants, and adult hippocampal neurogenesis: Insights for addiction and stem cell biology"],"prefix":"10.1002","volume":"16","author":[{"given":"Amelia J.","family":"Eisch","sequence":"first","affiliation":[]},{"given":"Gwyndolen 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