{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,2]],"date-time":"2023-11-02T17:06:06Z","timestamp":1698944766244},"reference-count":5,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,10,24]],"date-time":"2004-10-24T00:00:00Z","timestamp":1098576000000},"content-version":"vor","delay-in-days":14176,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Helvetica Chimica Acta"],"published-print":{"date-parts":[[1966,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The distinction between derivatives of penicilloic acids with modified \u03b1\u2010carboxyl function and the corresponding penicilloic acids themselves by means of a photometric test is described. The procedure involves conversion of the penicillin derivatives to penamaldates by the action of mercuric chloride, and comparison of the stability of the extinction at 282 nm in phosphate buffer at pH 7,4. The stabilities of the free penamaldates made from penicilloic acids are quite low (half life 4 to 5 minutes) and contrast with the high stabilities of penamaldoyl derivatives obtained from the \u03b1\u2010derivatives of penicilloic acids. Some characteristics of the method are discussed, and its potential usefulness for the quantitative analysis of mixtures of penicilloic acid and \u03b1\u2010derivatives of penicilloic acid is demonstrated.<\/jats:p>","DOI":"10.1002\/hlca.19660490531","type":"journal-article","created":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T23:33:39Z","timestamp":1103844819000},"page":"1689-1694","source":"Crossref","is-referenced-by-count":30,"title":["Unterscheidung der Penicilloins\u00e4uren von funktionellen Derivaten ihrer. \u03b1\u2010Carboxylgruppe mittels Penamaldat\u2010Stabilit\u00e4tsbestimmung"],"prefix":"10.1002","volume":"49","author":[{"given":"C. H.","family":"Schneider","sequence":"first","affiliation":[]},{"given":"A. L.","family":"De Weck","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2004,10,24]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.115.4.821"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1021\/jm01240a016"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"415ff","DOI":"10.1515\/9781400874910-015","volume-title":"The Chemistry of Penicillin","author":"Woodward R. B.","year":"1949"},{"key":"e_1_2_1_5_2","unstructured":"C. H.Schneider&A. L.de Weck Biochim. biophsica Acta(in Vorbereitung)."},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hlca.19660490532"}],"container-title":["Helvetica Chimica Acta"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fhlca.19660490531","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hlca.19660490531","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T10:27:24Z","timestamp":1697711244000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hlca.19660490531"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1966,1]]},"references-count":5,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1966,1]]}},"alternative-id":["10.1002\/hlca.19660490531"],"URL":"https:\/\/doi.org\/10.1002\/hlca.19660490531","archive":["Portico"],"relation":{},"ISSN":["0018-019X","1522-2675"],"issn-type":[{"value":"0018-019X","type":"print"},{"value":"1522-2675","type":"electronic"}],"subject":[],"published":{"date-parts":[[1966,1]]}}}