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Likewise, the formation of polyribosomes was inhibited in interferon\u2010treated cultures although no effect was observed on the formation of the ribosomal subunits. As control cells and interferon\u2010treated cells continued to multiply and the cultures attained cell density saturation, the differences in macromolecular synthesis and polyribosome formation between the cultures became less marked. Confidence that interferon itself was responsible for the effects observed stemmed from the use of highly purified interferon preparations and the availability, as a cell control, of a subline of L1210 cells resistant to interferon action. The possibility that a single mechanism of action is common to the antiviral effect of interferon and its effect on cell division is discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910120126","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T14:17:49Z","timestamp":1171894669000},"page":"250-258","source":"Crossref","is-referenced-by-count":18,"title":["Interferon and cell division. VIII. 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