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The cell lines arising in the co\u2010cultures were of mixed origin, with foetal cells predominating in many cases. In contrast, when mononuclear cells from seronegative adult donors were first infected with EB virus <jats:italic>in vitro<\/jats:italic> and then 5 to 12 days later co\u2010cultured with a large excess of foetal cells of the opposite sex, the cell lines which arose were almost exclusively derived from the adult donor despite the fact that a small minority of the virus\u2010infected adult cells released infectious virus capable of transforming the co\u2010cultivated foetal cells. The experiments suggest that EB virus\u2010infected cells present in the blood of IM patients and seropositive donors do not possess the capacity for unlimited <jats:italic>in vitro<\/jats:italic> growth shown by seronegative adult donor lymphocytes experimentally infected with the virus.<\/jats:p>","DOI":"10.1002\/ijc.2910190606","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T16:53:41Z","timestamp":1171904021000},"page":"775-782","source":"Crossref","is-referenced-by-count":43,"title":["Comparative studies on adult donor lymphocytes infected by EB virus <i>in vivo<\/i> or <i>in vitro<\/i>: Origin of transformed cells arising in co\u2010cultures with foetal lymphocytes"],"prefix":"10.1002","volume":"19","author":[{"given":"A. B.","family":"Rickinson","sequence":"first","affiliation":[]},{"given":"S.","family":"Finerty","sequence":"additional","affiliation":[]},{"given":"M. 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