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At a standard dose of 10,000 U\/ml, incorporation of tritiated thymidine ([<jats:sup>3<\/jats:sup>H] TdR) was reduced by 7\u201392% of control values, and cell survival by 35\u201382% in acute myelogenous leukaemia cell cultures, whereas in normal bone\u2010marrow cultures interferon showed a 58\u201362% reduction in [<jats:sup>3<\/jats:sup>H] TdR uptake but only up to 13% reduction in cell survival. [<jats:sup>3<\/jats:sup>H] TdR incorporation by MLC\u2010stimulated lymphocytes was also significantly reduced by interferon but the blastogenic response to PHA was not. These effects of interferon were shown to be dose\u2010dependent. The problems of using interferon in the treatment of AML in the light of these findings are discussed.<\/jats:p>","DOI":"10.1002\/ijc.2910200405","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:06:24Z","timestamp":1171904784000},"page":"500-505","source":"Crossref","is-referenced-by-count":50,"title":["Growth inhibitory effects of interferon on normal and malignant human haemopoietic cells"],"prefix":"10.1002","volume":"20","author":[{"given":"Frances R.","family":"Balkwill","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T. D.","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"87","article-title":"Morphological characterisation of adult acute leukaemia in short\u2010term liquid culture. 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