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The plasma cells that stained positively for gamma, mu, alpha, or delta chains varied greatly in number from case to case, depending somewhat on the histologic type of the disease. Hodgkin (H) and Sternberg\u2010Reed (SR) cells that stained for gamma chains were the most frequent, followed by those positive for delta chains. H and SR cells positive for mu or alpha chains were usually sparse. In 11 cases gamma and delta chains were present simultaneously in single cells. No other combination of heavy\u2010chain classes could be found in H and SR cells. In five cases of the lymphocytic\u2010depletion type, the Clg was restricted to one heavy\u2010chain class and one light\u2010chain type. Gamma\u2010chain subtypes were determined in a total of 24 cases. In the cases with one light\u2010chain type and in four other cases, only gamma, chains were present in the H and SR cells. In many cases the proportion of H and SR cells positive for each gamma\u2010chain subclass was not the same as that of the surrounding plasma cells. Variable numbers of H and SR cells showed unequivocal positivity for albumin in 12, alpha<jats:sub>1<\/jats:sub>\u2010antichymotrypsin in 12, and lysozyme in one out of the 44 cases tested. In 21 out of these 44 cases only Clg could be detected. The findings presented here are discussed in relation to the possible monocytoid\/macrophage or lymphoid B\u2010cell nature of H and SR cells. Our data provide evidence for both a lymphatic and a macrophage origin of H and SR cells. It is not possible to reconcile these data on the basis of present knowledge.<\/jats:p>","DOI":"10.1002\/ijc.2910210502","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:00:53Z","timestamp":1171904453000},"page":"531-541","source":"Crossref","is-referenced-by-count":86,"title":["The complexity of immunohistochemical staining pattern of hodgkin and sternberg\u2010reed cells\u2014demonstration of immunoglobulin, albumin, \u03b1<sub>1<\/sub>\u2010antichymotrypsin and lysozyme"],"prefix":"10.1002","volume":"21","author":[{"given":"Constantin S.","family":"Papadimitriou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harald","family":"Stein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl","family":"Lennert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.1.167"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(74)93138-9"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/258235a0"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(76)80283-9"},{"key":"e_1_2_1_6_1","first-page":"1095","article-title":"Two myeloma globulins, IgG1 kappa and IgG1 lambda, from a single patient. 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