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Six antigens (OvC\u20101, 2, 3, 4, 5 and 6), which could not be detected in normal ovary, were found in a variable proportion of ovarian tumors. Two of these antigens (OvC\u20104 and 5) proved to be previously recognized tissue antigens, carcinoembryonic antigen (CEA) and the related normal glycoprotein (NGP). A third antigen (OvC\u20103) was shown to be identical to pregnancy\u2010zone protein (PZP, SP<jats:sub>3<\/jats:sub>, PAG). It was detected in 20 of 93 epithelial cancers of the ovary and in 20 of 22 sera from ovarian cancer patients. OvC\u20106 was an individually specific antigen detectable only in the immunizing tumor. OvC\u20101 and OvC\u20102 are unrelated to well\u2010defined tumor antigens. The former was detectable in 48 of 93 epithelial cancers of the ovary, in some cervical, breast, gastric and pancreatic cancers and also in normal kidney and lung. Its presence in cord and pregnancy sera, and in placenta and amniotic fluid, indicates that it may be a new pregnancy\u2010associated protein. OvC\u20102 is confined to ovarian cancers (8\/93) and cannot be detected in tumors of other types or in normal adult tissues. Since it is present in placenta, amniotic fluid and fetal intestine it can be considered to be a fetal or differentiation antigen.<\/jats:p>","DOI":"10.1002\/ijc.2910210506","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T17:00:53Z","timestamp":1171904453000},"page":"570-577","source":"Crossref","is-referenced-by-count":40,"title":["Analysis of human ovarian tumor antigens using heterologous antisera: Detection of new antigenic systems"],"prefix":"10.1002","volume":"21","author":[{"given":"N.","family":"Imamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. O.","family":"Lloyd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"JR.","given":"J. 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