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In most recipients, passively\u2010transferred antibodies were replaced by endogenous antibodies regardless of whether donor or recipient had EBV antibodies before transplantation. Commencement or resumption of endogenous EBV antibody production was not associated with signs of infectious mononucleosis or heterophil antibody responses. Antibodies to VCA rose to abnormally high titers, followed successively by antibody to early antigens (EA), and disproportionately low levels of anti\u2010EBNA. Unusually high anti\u2010VCA and anti\u2010EA levels persisted when tests of immune function returned to normal. Antibodies to other herpes group viruses showed no consistent changes. We conclude that (1) EBV does not cause significant clinical problems in marrow transplant recipients; (2) persistent EBV infection can become established or reestablished in the presence of antibodies to EBV; (3) marrow transplant recipients show the same exaggerated immune response to EBV as other immunodeficient patients; and (4) the pattern of EBV\u2010specific antibodies may be a more sensitive measure of defective cell\u2010mediated immunity than most conventional tests of immune function.<\/jats:p>","DOI":"10.1002\/ijc.2910260205","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:02:59Z","timestamp":1171908179000},"page":"151-157","source":"Crossref","is-referenced-by-count":33,"title":["Epstein\u2010Barr virus\u2010related serology in marrow transplant recipients"],"prefix":"10.1002","volume":"26","author":[{"given":"Beverly","family":"Lange","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Werner","family":"Henle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joel D.","family":"Meyers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lily C.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles","family":"August","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Penelope","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan","family":"Arbeter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gertrude","family":"Henle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"723","volume-title":"Diagnostic procedures for viral and Rickettsial infection","author":"Benyesh\u2010Melnick M.","year":"1969"},{"key":"e_1_2_1_3_1","first-page":"196","article-title":"Epstein\u2010Barr virus related antibody patterns in ataxia\u2010telangiectasia","volume":"35","author":"Berkel A. 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