{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T14:38:18Z","timestamp":1784990298467,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9467,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1980,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A human leukemic cell line (THP\u20101) cultured from the blood of a boy with acute monocytic leukemia is described. This cell line had Fc and C3b receptors, but no surface or cytoplasmic immunoglobulins. HLA haplotypes of THP\u20101 were HLA\u2010A2, \u2010A9, \u2010B5, \u2010DRW1 and \u2010DRW2. The monocytic nature of the cell line was characterized by: (1) the presence of \u03b1\u2010naphthyl butyrate esterase activities which could be inhibited by NaF; (2) lysozyme production; (3) the phagocytosis of latex particles and sensitized sheep erythrocytes; and (4) the ability to restore T\u2010lymphocyte response to Con A. The cells did not possess Epstein\u2010Barr virus\u2010associated nuclear antigen. These results indicate that THP\u20101 is a leukemic cell line with distinct monocytic markers. During culture, THP\u20101 maintained these monocytic characteristics for over 14 months.<\/jats:p>","DOI":"10.1002\/ijc.2910260208","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:02:59Z","timestamp":1171908179000},"page":"171-176","source":"Crossref","is-referenced-by-count":1718,"title":["Establishment and characterization of a human acute monocytic leukemia cell line (THP\u20101)"],"prefix":"10.1002","volume":"26","author":[{"given":"Shigeru","family":"Tsuchiya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiko","family":"Yamabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuko","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tasuke","family":"Konno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiya","family":"Tada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/270347a0"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.136.1.191"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107525"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197811)42:5<2379::AID-CNCR2820420539>3.0.CO;2-4"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107124"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-124-31677"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910230206"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0145-2126(77)90063-7"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1978.40"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.306682"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/279328a0"},{"key":"e_1_2_1_13_1","first-page":"982","article-title":"Studies of surface immunoglobulins on human B lymphocytes. 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