{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T04:28:51Z","timestamp":1750480131250},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":9406,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1980,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>At the time of treatment in 1977 for primary breast cancer of all stages, the tumors of 270 women were examined for estrogen\u2010receptor (ER) content by iso\u2010electric focusing on polyacrylamide gel. The procedures for the initial and follow\u2010up examinations were standardized. Postoperative adjuvant radiotherapy or chemotherapy was given to pre\u2010 and postmenopausal women aged up to 70 years with nodal involvement. Adjuvant tamoxifen treatment (20 mg twice daily for 2 years) was given to one\u2010half of the postmenopausal patients aged 70 years or less, selected at random, and irrespective of any other adjuvant therapy. These forms of treatment appeared not to introduce bias into the results of the study. There was no correlation between the ER content and tumor spread. Symptom\u2010free survival during the follow\u2010up period was best for the patients with tumors with a high ER content, poorer for the patients with tumors of intermediate ER content and least favorable for patients with tumors having low ER content. (Ranges for high, intermediate and low levels: 2.18\u20109.08, 0.13\u20102.17 and 0\u20100.12 fmoles\/\u03bcg DNA). The differences between the survival curves were significant. For the 120 operable patients with nodal involvement there were also significant differences in recurrence\u2010free survival. The premenopausal patients in this group likewise showed a significant difference in survival with respect to ER content. For the operable patients with nodal involvement and poorly differentiated tumors there was also a difference in the survival rate depending on the ER content. In this study the ER content of breast cancer was shown to be a quantitative rather than a qualitative entity. The study confirms the independent prognostic importance of the ER content and points to its potential value as a stratification criterion in adjuvant therapy trials.<\/jats:p>","DOI":"10.1002\/ijc.2910260407","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:01:10Z","timestamp":1171908070000},"page":"429-433","source":"Crossref","is-referenced-by-count":41,"title":["Estrogen receptor level and other factors in early recurrence of breast cancer"],"prefix":"10.1002","volume":"26","author":[{"given":"H.","family":"Westerberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. A.","family":"Gustafson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Nordenskj\u00f6ld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Silfversw\u00e4rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Wallgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1971.80"},{"key":"e_1_2_1_3_1","first-page":"1271","article-title":"Association between steroid hormone receptor status and disease\u2010free interval in breast cancer","volume":"63","author":"Allegra J. C.","year":"1979","journal-title":"Cancer Treat. 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V.","year":"1975","journal-title":"Cancer Res."},{"key":"e_1_2_1_12_1","first-page":"4669","article-title":"Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer","volume":"37","author":"Knight W. A.","year":"1977","journal-title":"Cancer Res."},{"key":"e_1_2_1_13_1","first-page":"4292","article-title":"Estrogen receptor assay in primary breast cancer and early recurrence of the disease","volume":"38","author":"Maynard P. V.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1978.282"},{"key":"e_1_2_1_15_1","series-title":"2nd series","volume-title":"Atlas of tumor pathology","author":"McDivtt R. W.","year":"1969"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_1_17_1","first-page":"4296","article-title":"Prognostic value of estrogen receptor determinations in patients with breast cancer","volume":"38","author":"Rich M. A.","year":"1978","journal-title":"Cancer Res."},{"key":"e_1_2_1_18_1","volume-title":"International histological classification of tumors","author":"Scarff R. 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