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Dissociation constants for the complex of interferon and receptor site were of the order 10<jats:sup>\u22129<\/jats:sup>\u201310<jats:sup>\u221211<\/jats:sup> M. All human cells tested showed such binding. Occupation of these high\u2010affinity sites, at 37\u00b0C, was compared with the inhibition of cellular growth due to interferon. The most sensitive cell line (Daudi) gave a complete biological response with only a fraction of its sites occupied. Evidence of two sites was found for a line (P3HRI) showing intermediate sensitivity. A relatively insensitive line (Raji) showed no response when all its high\u2010affinity sites were occupied.<\/jats:p>","DOI":"10.1002\/ijc.2910280508","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T18:49:32Z","timestamp":1171910972000},"page":"575-582","source":"Crossref","is-referenced-by-count":87,"title":["Binding of <sup>125<\/sup>I\u2010labelled human \u03b1interferon to human lymphoid cells"],"prefix":"10.1002","volume":"28","author":[{"given":"Knud Erik","family":"Mogensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie\u2010Th\u00e9r\u00e8se","family":"Bandu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franloise","family":"Vignaux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Aguet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ion","family":"Gresser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,20]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-28-2-207"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/284459a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","unstructured":"Aguet M. andBlanchard B. 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