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Though a fairly high level of dsRNA\u2010dependent 2\u2032\u20105\u2032\u2010oligoadenylate synthetase (2\u20135A synthetase) was found in Daudi cells, treatment of these cells with IFN\u2010\u03b1 and \u03b2 enhanced the enzyme level in cells at least four\u2010fold, but IFN\u2010\u03b3 did not show any such effect. Lymphoblastoid Raji cells were insensitive to the antiviral and anticellular activities of IFN\u2010\u03b1, \u03b2 and \u03b3, but 2\u20105A synthetase was induced in cells by the treatment with IFN\u2010\u03b1 and \u03b2, though the enzyme level was lower than that found in interferon\u2010treated Daudi cells. Human leukemic K562 cells were completely insensitive to IFN\u2010\u03b1, \u03b2 and at the same time to IFN\u2010\u03b3 with regard to the antiviral, anticellular activities and to the induction of 2\u20105A synthetase.<\/jats:p>","DOI":"10.1002\/ijc.2910300206","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:19:09Z","timestamp":1171912749000},"page":"161-165","source":"Crossref","is-referenced-by-count":29,"title":["Effects of human \u03b3 interferon on cell growth, replication of virus and induction of 2\u2032\u20105\u2032oligoadenylate synthetase in three human lymphoblastoid cell lines and K562 cells"],"prefix":"10.1002","volume":"30","author":[{"given":"Yoshimi","family":"Tomita","sequence":"first","affiliation":[]},{"given":"Kari","family":"Cantell","sequence":"additional","affiliation":[]},{"given":"Tsuguo","family":"Kuwata","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-28-2-207"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(81)90241-5"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.77.5.2528"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"8390","DOI":"10.1016\/S0021-9258(18)43505-3","article-title":"Mechanism of action of human interferons","volume":"255","author":"Baglioni C.","year":"1980","journal-title":"J. biol. 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