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A marked heterogeneity of responses was noted to many of the agents studied, including X\u2010irradiation. However, in terms of ID<jats:sub>70<\/jats:sub> values for 24\u2010h drug exposures, comparable responses in all the cell lines tested, with values falling within a 1.4\u2010 to 2.9\u2010fold range, were noted with actinomycin D, adriamycin, m\u2010AMSA<jats:sup>4<\/jats:sup>, dibromodulcitol, 5\u2010fluorouracil, hydroxyurea and ICRF\u2010159. In contrast, mixed responses to cis\u2010platinum and methotrexate were particularly marked, with ID<jats:sub>70<\/jats:sub> values differing by factors of 3.8 and 7.5 respectively. In addition, when higher drug concentrations of m\u2010AMSA, cis\u2010platinum, dibromodulcitol and ICRF\u2010159 were employed, significant deviations in the four survival curves became apparent. Continuous exposure to diethylstilboestrol and medroxyprogesterone acetate caused negligible cell kill. Due to these variable responses it was not possible to predict that any agent tested might have specific value in the treatment of prostate cancer. However, preliminary <jats:italic>in vitro<\/jats:italic> screening with such a panel of cell lines may complement <jats:italic>in vivo<\/jats:italic> studies with models of prostatic cancer and prove useful in investigations of mechanisms of drug resistance.<\/jats:p>","DOI":"10.1002\/ijc.2910320315","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T19:31:20Z","timestamp":1171913480000},"page":"351-358","source":"Crossref","is-referenced-by-count":10,"title":["<i>In vitro<\/i> responses of human prostate tumour cell lines to a range of antitumour agents"],"prefix":"10.1002","volume":"32","author":[{"given":"Sylvia A.","family":"Metcalfe","sequence":"first","affiliation":[]},{"given":"Richard D. H.","family":"Whelan","sequence":"additional","affiliation":[]},{"given":"John R. 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