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By co\u2010cultivation with human umbilical cord\u2010blood cells and\/or in the presence of interleukin\u20102, lymphoid cell lines were successfully established from the chimpanzee, African green monkey, pig\u2010tailed macaque, red\u2010faced macaque, Formosan monkey, Japanese monkey and bonnet monkey that had antibodies against HTLV antigens. These cell lines reacted with human sera of ATL patients and monoclonal antibodies against p19 and p24 of HTLV antigens. Cellular DNAs contained the provirus sequences homologous to HTLV\u2010I by Southern blot hybridization. Moreover, they produced extracellular type\u2010C virus particles and RNA\u2010dependent DNA polymerase. All of these lymphoid line cells had Tac antigen, interleukin\u20102 receptor, and those of chimpanzee and red\u2010faced macaque had helper\/inducer T\u2010cell markers, while those derived from African green monkey had suppressor\/cytotoxic T\u2010cell markers. Furthermore, simian HTLV\u2010related viruses of pig\u2010tailed macaque, red\u2010faced macaque and Japanese monkey were transmitted to human lymphocytes on co\u2010cultivation.<\/jats:p>","DOI":"10.1002\/ijc.2910350314","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T20:15:44Z","timestamp":1171916144000},"page":"377-384","source":"Crossref","is-referenced-by-count":40,"title":["Isolation of simian retroviruses closely related to human T\u2010cell leukemia virus by establishment of lymphoid cell lines from various non\u2010human primates"],"prefix":"10.1002","volume":"35","author":[{"given":"Hajime","family":"Tsujimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsumi","family":"Komuro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Iijima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junko","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koh\u2010Ichi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Hayami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-395561-6.50012-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.158.6.1895"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6200936"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1182\/blood.V60.3.545.545","article-title":"Retroviruses as etiologic agents of some animal and human leukemias and lymphomas and as tools for elucidating the molecular mechanism of leukemogenesis","volume":"60","author":"Gallo R. 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Watanabe T. Miyoshi I. Hayami M. Tsujimoto H. Seiki M. andYoshida M. 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