{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T16:03:04Z","timestamp":1772899384982,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":6028,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 51 biopsies derived from the same number of patients with established invasive squamous\u2010cell carcinoma of the esophagus in Linxian, a high\u2010risk area for esophageal cancer in China, were analyzed histologically and by <jats:italic>in situ<\/jats:italic> DNA hybridization to demonstrate human papillomavirus (HPV) infection. Epithelial changes suggesting HPV infection within or adjacent to the carcinoma lesions were found in 25 cases (49.0%). Esophageal lesions with HPV morphology showed both flat (25 cases) and inverted condylomas (2 cases) resembling those found in the genital tract. HPV 6, 11, 16 or 18 DNA sequences were detected in 22\/51 (43.1%) of the esophageal specimens. HPV DNA was most frequently localized in epithelium adjacent to carcinomas in areas showing either epithelial hyperplasia (36.1%) or dysplasia (22.2%). Of the lesions with morphological HPV changes, 64% (16\/22) were shown to contain HPV DNA. In 2 specimens, HPV DNA was found in frankly malignant cells. High\u2010risk types HPV 16 and\/or 18 DNA sequences were found in 16 of the 22 HPV DNA\u2010positive cases (72.7%). Our results confirm previously reported HPV involvement in esophageal squamous\u2010cell lesions, and support the hypothesis of HPV as a possible etiological agent in esophageal carcinogenesis.<\/jats:p>","DOI":"10.1002\/ijc.2910450106","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:00:18Z","timestamp":1171922418000},"page":"21-25","source":"Crossref","is-referenced-by-count":94,"title":["Human papillomavirus (HPV) DNA in esophageal precancer lesions and squamous cell carcinomas from China"],"prefix":"10.1002","volume":"45","author":[{"given":"Fuju","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiong","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxiu","family":"Ji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Syrj\u00e4nen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_1_1","first-page":"6","article-title":"Oesophageal carcinoma\u2013search for a possible viral aetiology using molecular hybridization techniques","volume":"71","author":"Brooks L. A.","year":"1987","journal-title":"S. Afr. med. J."},{"key":"e_1_2_1_2_1","first-page":"39","article-title":"Papillomas and cancer in cattle","volume":"6","author":"Campo M. S.","year":"1987","journal-title":"Cancer Surv."},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1018542"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(79)90236-8"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910340503"},{"key":"e_1_2_1_6_1","first-page":"487","article-title":"Squamous papilloma of the esophagus diagnosed by cytology: report of a case with concurrent occult epidermoid carcinoma","volume":"30","author":"De Borges R. J.","year":"1986","journal-title":"Acta Cytol."},{"key":"e_1_2_1_7_1","first-page":"161","article-title":"Papillomaviruses and their association with cancer in animals and in man","volume":"3","author":"Gissmann L.","year":"1984","journal-title":"Cancer Surv."},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.251.17.2185"},{"key":"e_1_2_1_9_1","first-page":"441","article-title":"Human papillomavirus infection related to oesophageal carcinoma in black South Africians","volume":"69","author":"Hille J. J.","year":"1986","journal-title":"S. Afr. med. J."},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(88)90459-0"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/274215a0"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910220316"},{"key":"e_1_2_1_13_1","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/jnci\/59.4.1127","article-title":"Oesophageal cancer studies in the Caspian littoral of Iran: results of population studies\u2013a prodome","volume":"59","author":"JOINT IRAN\/IARC STUDY GROUP","year":"1977","journal-title":"J. nat. Cancer Inst."},{"key":"e_1_2_1_14_1","first-page":"343","volume-title":"Advances in modern human nutrition","author":"Kmet J.","year":"1980"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90187-X"},{"key":"e_1_2_1_16_1","first-page":"166","article-title":"Pr\u00e9sence d'un antig\u00e8ne viral du groupe \u201cPapilloma\u201d dans un condylome oesophagien chez l'homme","volume":"9","author":"Lesec G.","year":"1985","journal-title":"Gastroent\u00e9rol. clin. Biol."},{"key":"e_1_2_1_17_1","first-page":"505","article-title":"Condylomatous lesions of the cervix and vagina: 1. Cytologic patterns","volume":"20","author":"Meisels A.","year":"1976","journal-title":"Acta Cytol."},{"key":"e_1_2_1_18_1","first-page":"7","article-title":"Human papillomavirus infection of the cervix. The atypical condyloma","volume":"25","author":"Meisels A.","year":"1981","journal-title":"Acta Cytol."},{"key":"e_1_2_1_19_1","first-page":"15","article-title":"Langerhans cells, papillomaviruses and oesophageal carcinoma\u2013a hypothesis","volume":"71","author":"Morris H. H. B.","year":"1987","journal-title":"S. Afr. med. J."},{"key":"e_1_2_1_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(82)92151-1"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910360210"},{"key":"e_1_2_1_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860601)57:11<2222::AID-CNCR2820571125>3.0.CO;2-3"},{"key":"e_1_2_1_23_1","first-page":"112","article-title":"Biology and biochemistry of papillomaviruses","volume":"99","author":"Pfister H.","year":"1984","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"e_1_2_1_24_1","first-page":"12","article-title":"Cytohistopathology of the early cancer of the esophagus and its related lesion","volume":"2","author":"Shen Qiong","year":"1988","journal-title":"J. Henan med. Univ."},{"key":"e_1_2_1_25_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.167.1.225"},{"key":"e_1_2_1_26_1","first-page":"283","article-title":"Histological changes identical to those of condylomatous lesions found in esophageal squamous cell carcinomas","volume":"52","author":"Syrj\u00e4nen K. J.","year":"1982","journal-title":"Arch. Geschwulstforsch."},{"key":"e_1_2_1_27_1","first-page":"53","article-title":"Human papillomavirus (HPV) infections of the female genital tract and their associations with intraepithelial neoplasia and squamous\u2010cell carcinoma","volume":"21","author":"Syrj\u00e4nen K.","year":"1986","journal-title":"Path. Ann."},{"key":"e_1_2_1_28_1","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-642-71097-1","volume-title":"Papilomaviruses and human disease","author":"Syrj\u00e4nen K.","year":"1987"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(88)90017-1"},{"key":"e_1_2_1_30_1","first-page":"291","article-title":"Squamous cell papilloma of the oesophagus: a tumor probably caused by human papilloma virus (HPV)","volume":"5","author":"Syrj\u00e4nen K.","year":"1982","journal-title":"Diag. Histopathol."},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-0934(86)90031-5"},{"key":"e_1_2_1_32_1","first-page":"449","article-title":"\u201cHPV score\u201d, a scoring system for histological diagnosis of human papillomavirus infection in dysplasia of the uterine cervix","volume":"37","author":"Toki T.","year":"1987","journal-title":"Acta pathol. jap."},{"key":"e_1_2_1_33_1","first-page":"391","article-title":"Squamous papilloma of the esophagus: case report and review of the literature","volume":"50","author":"Weitzner S.","year":"1968","journal-title":"Amer. J. Gastroenterol."},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850101)55:1<149::AID-CNCR2820550123>3.0.CO;2-9"},{"key":"e_1_2_1_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196103\/04)14:2<389::AID-CNCR2820140220>3.0.CO;2-E"},{"key":"e_1_2_1_36_1","first-page":"2633","article-title":"Research on esophageal cancer in China: a review","volume":"40","author":"Yang C. S.","year":"1980","journal-title":"Cancer Res."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-66800-5_1"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910450106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910450106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T02:46:34Z","timestamp":1698029194000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910450106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,1,15]]},"references-count":37,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1990,1,15]]}},"alternative-id":["10.1002\/ijc.2910450106"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910450106","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1990,1,15]]}}}