{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T05:50:26Z","timestamp":1774677026636,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":5815,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1990,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Different treatment schedules have been investigated when evaluating the inhibitory effect of 9\u2010(2\u2010phosphonylmethoxyethyl)adenine (PMEA) and 3\u2032 \u2010azido\u20102\u2032, 3\u2032 \u2010dideoxythymidine (AZT) on the replication of human immunodeficiency virus type I (HIV\u20101) in MT\u20104 cells, transformation of C3H\/3T3 cells by Moloney murine sarcoma virus (MSV), and MSV\u2010induced tumor formation in newborn NMRI mice. Shortening the exposure time of HIV\u20101\u2010infected MT\u20104 cells to PMEA or AZT led to an increase in the selectivity index of both compounds. PMEA proved markedly more efficient in suppressing MSV\u2010induced tumor formation in mice when administered as a single dose on the day of infection than when these doses were spread over 2, 4 or 7 administrations within 1 week after the virus infection. This was not observed when the total dose of AZT was fractionated. While the infrequent dosage regimen increased the anti\u2010retrovirus activity of PMEA, it did not increase its toxicity for the host. This unique property makes PMEA an attractive candidate for the treatment of retrovirus infections, including AIDS.<\/jats:p>","DOI":"10.1002\/ijc.2910460233","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T21:53:52Z","timestamp":1171922032000},"page":"337-340","source":"Crossref","is-referenced-by-count":37,"title":["Anti\u2010retrovirus activity of 9\u2010(2\u2010phosphonylmethoxyethyl)adenine (pmea) <i>in vivo<\/i> increases when it is less frequently administered"],"prefix":"10.1002","volume":"46","author":[{"given":"Jan","family":"Balzarini","sequence":"first","affiliation":[]},{"given":"Lieve","family":"Naesens","sequence":"additional","affiliation":[]},{"given":"Erik De","family":"Clercq","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","volume-title":"Proceedings of the International TNO Meeting on \u201cAnimal models in AIDS\u201d","author":"Balzarini J.","year":"1990"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910450319"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0166-3542(89)90001-6"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"6126","DOI":"10.1016\/S0021-9258(18)83322-1","article-title":"Differential patterns of intracellular metabolism of 2\u2032, 3\u2032 \u2010didehydro\u20102\u2032, 3\u2032 \u2010dideoxythymidine and 3\u2032 \u2010azido\u20102\u2032, 3\u2032 \u2010dideoxythymidine, two potent anti\u2010human immunodeficiency virus compounds","volume":"264","author":"Balzarini J.","year":"1989","journal-title":"J biol. Chem."},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.1.332"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.3181\/00379727-137-35627"},{"key":"e_1_2_1_8_1","doi-asserted-by":"crossref","unstructured":"Egberink H. F. Borst M. A. J. Niphuis H. Balzarini J. Neu H. Schellekens H. De Clercq E. HorzinekM. C.andKoolen M. J. M. Inhibition of feline immunodeficiency virus infection by 9\u2010(2\u2010phosphonylmethoxyethyl)adenine.Proc. nat. Acad. Sci. (Wash.)(1990). (In press).","DOI":"10.1073\/pnas.87.8.3087"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.33.11.1864"},{"key":"e_1_2_1_10_1","volume-title":"Intracellular metabolism of the anti\u2010herpes agent, (S)\u20101\u2010(3\u2010hydroxy\u20102\u2010phosphonylmethoxypropyl)\u2010cytosine (HPMPC). 29th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Houston, Abstract 713","author":"Hitchcock M. J. M.","year":"1989"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1135\/cccc19872801"},{"key":"e_1_2_1_12_1","volume-title":"29th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Houston. Abstract 751","author":"Kern E. R.","year":"1989"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1987.49"},{"key":"e_1_2_1_14_1","unstructured":"Naesens L. Balzarini J. Holy A. Rosenberg I.andDe Clercq E. Antiretroviral efficacy of 9\u2010(2\u2010phosphonylmethoxyethyl)adenine and 9\u2010(2\u2010phosphonylmethoxyethyl)\u20102 6\u2010diaminopurine in mice infected with Friend leukemia virus. Abstracts of the UCLA Symposia on molecular and cellular biology\u2010HIV and AIDS: pathogenesis therapy and vaccine. Keystone CO March 31\u2010April 6 1990 (1990). 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