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Moreover, in the absence of environmental stress, 2 lines (out of 6) expressed the \u201cinducible\u201d HSP72, which was also detectable in fresh tumor cells. HSP72 expression was not regulated during the cell cycle, in contrast with what has been observed with normal cells. Both HSP90 and HSP72 proteins exhibited a heterogeneous pattern of intracellular distribution in most cells, HSP72 being confined mainly to the nuclear compartment. Finally, we could detect both HSP90 and, to a lesser extent, HSP72 (that are generally believed to be located intracellularly) at the surface of some tumor cell lines. We conclude that tumor cells differ from normal cells in their pattern of HSP expression; this might imply a role of HSPs in eliciting an immune response against cancer.<\/jats:p>","DOI":"10.1002\/ijc.2910510418","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T22:56:19Z","timestamp":1171925779000},"page":"613-619","source":"Crossref","is-referenced-by-count":343,"title":["Unusual expression and localization of heat\u2010shock proteins in human tumor cells"],"prefix":"10.1002","volume":"51","author":[{"given":"Marina","family":"Ferrarini","sequence":"first","affiliation":[]},{"given":"Silvia","family":"Heltai","sequence":"additional","affiliation":[]},{"given":"M. Raffaella","family":"Zocchi","sequence":"additional","affiliation":[]},{"given":"Claudio","family":"Rugarli","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2188360"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90019-6"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0167-5699(90)90015-2","article-title":"Recognition of heat\u2010shock proteins and gamma delta cell function","volume":"11","author":"Born W.","year":"1990","journal-title":"Immunol. 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