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We have identified protein kinases expressed in a human breast\u2010cancer cell line, 600PEI, and a primary human breast carcinoma, using PCR cloning techniques based on consensus sequences in the kinase domain. Twenty\u2010five different protein kinases were isolated, including 3 novel putative tyrosine kinases (designated TKI, TK2, and TK5), and 2 novel putative cell\u2010cycle\u2010associated serine\/threonine kinases (designated STKI and STK2). TKI is a new member of the src family of kinases that is expressed predominantly in epithelial cells. TK2 is homologous to the receptor kinase, <jats:italic>HEK<\/jats:italic>, and TK5 appears to be another member of the J AK family of kinases. The novel serine\/threonine kinases, designated STKI and STK2, were homologous to the human cdc2 and the <jats:italic>Aspergillus nimA<\/jats:italic> genes. We subsequently analyzed the levels of expression of all of these protein kinases in a panel of human breast carcinomas, using PCR\u2010based methods. This analysis revealed different expression profiles in different primary breast carcinomas and, therefore, may determine new molecular sub\u2010sets of human.<\/jats:p>","DOI":"10.1002\/ijc.2910540409","type":"journal-article","created":{"date-parts":[[2007,2,19]],"date-time":"2007-02-19T23:09:27Z","timestamp":1171926567000},"page":"571-577","source":"Crossref","is-referenced-by-count":53,"title":["Novel protein kinases expressed in human breast cancer"],"prefix":"10.1002","volume":"54","author":[{"given":"William G.","family":"Cance","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rolf J.","family":"Craven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timothy M.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edison T.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(86)90779-8"},{"key":"e_1_2_1_3_1","first-page":"1036","article-title":"Sporadic amplification of the insulin\u2010like growth factor 1 receptor gene in human breast tumors","volume":"52","author":"Berns L. 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