{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:56:03Z","timestamp":1761918963438},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":4093,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,5,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Epstein\u2010Barr Virus (EBV) is implicated in the pathogenesis of endemic Burkitt's lymphoma (BL), B\u2010cell lymphomas occuring under immunosuppression, nasopharyngeal carcinoma and Hodgkin's disease. Two distinct patterns of latent EBV gene expression occur in EBV\u2010associated lymphomas. BLs typically display expression of the nuclear antigen EBNAI only, whereas EBV\u2010associated, non\u2010Burkitt B\u2010cell lymphomas express at least 9 latent viral genes (6 EBNAs and 3 latent membrane proteins), reminiscent of in vitro EBV\u2010immortalized lymphoblastoid cell lines (LCL). BLs are characterized by local, extra\u2010nodal growth, whereas EBV\u2010associated B\u2010cell lymphomas often disseminate to peripheral lymphoid tissue. We show here that BL cells forming local tumors after xenotransplantation into SCID mice disseminate to lymphoid tissue following introduction of the latent membrane protein 1 (LMP1) gene. Introduction of LMP1 into BL cells induced expression of CD44 on the cell surface, a molecule implicated in enhanced lymphoid tumor growth and dissemination. Introduction of CD44 into LMP1\u2010\/CD44\u2010BL cells was observed to confer the disseminated tumor growth pattern associated with LMP1 expression. Taken together our results show that expression of LMP1 may regulate expression of CD44 and play an important role in the behavior of EBV\u2010based lymphomas. \u00a9 <jats:italic>1995 Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910610315","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:53:03Z","timestamp":1171932783000},"page":"363-369","source":"Crossref","is-referenced-by-count":21,"title":["Induction of CD44 expression by the epstein\u2010barr virus latent membrane protein LMP1 is associated with lymphoma dissemination"],"prefix":"10.1002","volume":"61","author":[{"given":"J\u00fcrgen","family":"Walter","sequence":"first","affiliation":[]},{"given":"Volker","family":"Schirrmacher","sequence":"additional","affiliation":[]},{"given":"Donald","family":"Mosier","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90694-A"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/310207a0"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.4049\/jimmunol.130.4.1848","article-title":"Biosynthesis of glycosaminoglycans by epithelial and lymphocylic components of murine thymus","volume":"130","author":"Britz J. S.","year":"1983","journal-title":"J. Immnol."},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI114573"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.86.23.9558"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6401867"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/344777a0"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910420305"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199201023260103"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1128\/jvi.51.2.411-419.1984","article-title":"Nucleotide sequence of an mRNA transcribed in latent growth\u2010transforming virus infection indicates that it may encode a membrane protein","volume":"51","author":"Fennewald S.","year":"1984","journal-title":"J. Virol."},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/340393a0"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(91)90007-L"},{"key":"e_1_2_1_14_1","first-page":"1889","volume-title":"Virology","author":"Kieff E.","year":"1990"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(88)90530-2"},{"key":"e_1_2_1_16_1","first-page":"309","volume-title":"Burkitt's lymphoma: a human cancer model","author":"Lenoir G. M.","year":"1985"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.7.7.2299"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"4612","DOI":"10.1128\/jvi.66.7.4612-4616.1992","article-title":"Phenotypes of Epstein\u2010Barr virus LMP1 deletion mutants indicate transmembrane and amino\u2010terminal cytoplasmatic domains necessary for effects in B\u2010lymphoma cells","volume":"66","author":"Liebowitz D.","year":"1992","journal-title":"J. Virol."},{"key":"e_1_2_1_19_1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1128\/jvi.55.3.710-720.1985","article-title":"Epstein\u2010Barr virus protein found in the plasma membrane of transformed cells","volume":"55","author":"Mann K.","year":"1985","journal-title":"J. Virol."},{"key":"e_1_2_1_20_1","first-page":"1921","volume-title":"Virology","author":"Miller G.","year":"1990"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V78.5.1162.1162"},{"key":"e_1_2_1_22_1","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1182\/blood.V73.4.885.885","article-title":"Expression of lymphocyte homing receptor (CD44) as a mechanism of dissemination in non\u2010Hodgkin's lymphoma","volume":"73","author":"Pals S. T.","year":"1989","journal-title":"Blood"},{"key":"e_1_2_1_23_1","first-page":"496","article-title":"Expression of lymphocyte homing receptor antigen in non\u2010Hodgkin's lymphoma","volume":"130","author":"Picker L. J.","year":"1988","journal-title":"Amer. J. Pathol."},{"key":"e_1_2_1_24_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.1.352"},{"key":"e_1_2_1_25_1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1128\/jvi.66.1.122-131.1992","article-title":"Three pathways of Epstein\u2010Barr virus gene activation from EBNAl\u2010positive latency in B lymphocytes","volume":"66","author":"Rowe M.","year":"1992","journal-title":"J. Virol."},{"key":"e_1_2_1_26_1","doi-asserted-by":"crossref","first-page":"2599","DOI":"10.1002\/j.1460-2075.1986.tb04540.x","article-title":"Restricted expression of EBV latent genes and T lymphocyte detected membrane antigen in Burkitt's lymphoma cells","volume":"5","author":"Rowe D. T.","year":"1986","journal-title":"Emboj."},{"key":"e_1_2_1_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1987.tb02568.x"},{"key":"e_1_2_1_28_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.173.1.147"},{"key":"e_1_2_1_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(89)90638-7"},{"key":"e_1_2_1_30_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.174.4.859"},{"key":"e_1_2_1_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910500217"},{"key":"e_1_2_1_32_1","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1128\/jvi.64.5.2309-2318.1990","article-title":"Epstein\u2010Barr virus latent membrane protein (LMP1) and nuclear proteins 2 and 3C are effectors of phenotypic changes in B lymphocytes: EBNA2 and LMP1 cooperatively induce CD23","volume":"64","author":"Wang F.","year":"1990","journal-title":"J. Virol."},{"key":"e_1_2_1_33_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.65.8.4101-4106.1991"},{"key":"e_1_2_1_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(85)90256-9"},{"key":"e_1_2_1_35_1","doi-asserted-by":"crossref","first-page":"2337","DOI":"10.1128\/jvi.62.7.2337-2346.1988","article-title":"The truncated form of the Epstein\u2010Barr virus latent infection membrane protein expressed in virus replication does not transform rodent fibroblasts","volume":"62","author":"Wang D.","year":"1988","journal-title":"J. Virol."},{"key":"e_1_2_1_36_1","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1128\/jvi.62.11.4173-4184.1988","article-title":"Epstein\u2010Barr virus latent infection membrane protein alters the human B\u2010lymphocyte phenotype: deletion of the aminoterminus abolishes activity","volume":"62","author":"Wang D.","year":"1988","journal-title":"J. Virol."},{"key":"e_1_2_1_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(90)90695-B"},{"key":"e_1_2_1_38_1","first-page":"3095","article-title":"Suppression of the malignant phenotype in somatic cell hybrids between Burkitt's lymphoma cells and Epstein\u2010Barr virus\u2010immortalized lymphoblastoid cells despite deregulated c\u2010myc expression","volume":"50","author":"Wolf J.","year":"1990","journal-title":"Cancer Res."},{"key":"e_1_2_1_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-4608(93)90158-I"},{"key":"e_1_2_1_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910530416"},{"key":"e_1_2_1_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/313812a0"}],"container-title":["International Journal of Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fijc.2910610315","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ijc.2910610315","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T19:20:48Z","timestamp":1698261648000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ijc.2910610315"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,5,4]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1995,5,4]]}},"alternative-id":["10.1002\/ijc.2910610315"],"URL":"https:\/\/doi.org\/10.1002\/ijc.2910610315","archive":["Portico"],"relation":{},"ISSN":["0020-7136","1097-0215"],"issn-type":[{"value":"0020-7136","type":"print"},{"value":"1097-0215","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,5,4]]}}}