{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T13:02:01Z","timestamp":1761742921781},"reference-count":18,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2006,7,18]],"date-time":"2006-07-18T00:00:00Z","timestamp":1153180800000},"content-version":"vor","delay-in-days":3959,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,9,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An EBV variant has been identified in NPC tissues in Taiwan. This EBV variant contains a point mutation in exon I of the LMP I gene. This mutation results in the loss of an Xhol site at nt 169,426, which is present in strain B9S\u20108. In addition, this variant contains a 30\u2010bp deletion in exon 3 of the gene. The recent demonstration of the prevalence of EBV\u2010containing nasal and peripheral T\u2010cell lymphoma in this region drove us to evaluate the presence of this NPC\u2010EBV strain in 7 cases of T\u2010cell lymphoma, as well as in 48 NPC tissues, 2 cases of Hodgkin's disease and I B\u2010cell lymphoma. Four samples of normal lymph\u2010 node tissue, 40 of normal nasopharynx tissue and 78 throat washings of healthy individuals were included for comparison. We used sequence\u2010specific primers and the polymerase chain reaction (PCR) method to amplify LMP I gene fragments containing these variations. Mutations were then confirmed by restriction\u2010enzyme digestion and the DNA sequencing analysis. Our results showed that 57 of 58 tumor\u2010tissues samples were EBV\u2010positive. Among them, 56, including 6 T\u2010cell\u2010lymphoma samples, belonged to the NPC strain. This strain of EBV was also present in 92% of EBV\u2010positive normal nasopharynx tissues and in 84% of EBV\u2010positive throat washings of the healthy individuals tested. These results suggest that the NPC\u2010EBV strain is prominently present in Taiwan. \u00a9 1995 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/ijc.2910620605","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T00:45:37Z","timestamp":1171932337000},"page":"673-677","source":"Crossref","is-referenced-by-count":59,"title":["Detection of an epstein\u2010barr\u2010virus variant in T\u2010cell\u2010lymphoma tissues identical to the distinct strain observed in nasopharyngeal carcinoma in the taiwanese population"],"prefix":"10.1002","volume":"62","author":[{"given":"Yu\u2010Sun","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ih\u2010Jen","family":"Su","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei\u2010Jung","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chih\u2010Hung","family":"Shu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Koon","family":"Ng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shao\u2010Jung","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih\u2010Tung","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,18]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"2131","article-title":"Cloning and characterization of the latent membrane protein (LMP) of a specific Epstein\u2010Barr\u2010virus variant derived form the nasopharyngeal carcinoma in the Taiwanese population","volume":"7","author":"Chen M. 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