{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T12:27:30Z","timestamp":1759580850543},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,17]],"date-time":"2006-07-17T00:00:00Z","timestamp":1153094400000},"content-version":"vor","delay-in-days":3885,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Intl Journal of Cancer"],"published-print":{"date-parts":[[1995,11,27]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sequential activation of <jats:italic>bcl\u2010<\/jats:italic>2 and c\u2010<jats:italic>myc<\/jats:italic> appears to be involved in the pathogenesis of rare <jats:italic>de novo<\/jats:italic> acute lymphoid leukemias bearing both t(8; 14) and t(14;18). Acquisition of t(8;14) by follicular\u2010lymphoma cells with t(14;18) has also been related to the clinical transformation into an overt acute lymphoid leukemia in rare cases reported, and a role for c\u2010<jats:italic>myc<\/jats:italic> involvement in the progression of some follicular lymphomas with t(14;18) has been suggested by the detection of c\u2010<jats:italic>myc<\/jats:italic> rearrangements in association with histologic transformation. However, c\u2010<jats:italic>myc<\/jats:italic> abnormalities different from those observed in Burkitt's lymphoma have been reported in diffuse large\u2010cell lymphomas with breakpoints in 8q24, and a t(8;14) molecularly different from the classical one has been found in follicular lymphomas without t(14;18). We report the preliminary characterization of the EBV\u2010negative cell line U 2904 established from a transformed follicular lymphoma that carries both t(8;14) (q24;q32) and t(14;18) (q32;q21) translocations. U 2904 cells have a mature B\u2010cell phenotype, grow in agarose and are tumorigenic in nude mice. Rearrangements of both c\u2010<jats:italic>myc<\/jats:italic> and <jats:italic>bcl\u20102<\/jats:italic> confirmed the involvement of both oncogenes in the translocations which lead to abundant c\u2010<jats:italic>myc<\/jats:italic> and <jats:italic>bcl\u20102<\/jats:italic> transcripts. Two <jats:italic>JH<\/jats:italic> rearrangements and one <jats:italic>C\u03b1<\/jats:italic> rearrangement were observed which did not co\u2010migrate with either c\u2010<jats:italic>myc<\/jats:italic> or <jats:italic>bcl<\/jats:italic>\u20102 rearrangements. This is the first report of a cell line bearing both t(8;14) and t(14;18) derived from a follicular lymphoma after documented transformation into a centroblas\u2010tic lymphoma without leukemic features. U 2904 provides further evidence for the involvement of c\u2010<jats:italic>myc<\/jats:italic> in the progression of follicular lymphomas. \u00a9 1995 <jats:italic>Wiley\u2010Liss, Inc<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/ijc.2910630517","type":"journal-article","created":{"date-parts":[[2007,2,20]],"date-time":"2007-02-20T01:11:26Z","timestamp":1171933886000},"page":"710-715","source":"Crossref","is-referenced-by-count":8,"title":["A novel human B\u2010cell line (U\u20102904) bearing t(8;14) and t(14;18) translocations"],"prefix":"10.1002","volume":"63","author":[{"given":"Clara","family":"Sambade","sequence":"first","affiliation":[]},{"given":"Jan","family":"S\u00e1llstr\u00f6m","sequence":"additional","affiliation":[]},{"given":"Helena J.","family":"Wiklund","sequence":"additional","affiliation":[]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[]},{"given":"Syrje","family":"Kivi","sequence":"additional","affiliation":[]},{"given":"F\u00e1tima","family":"Gartner","sequence":"additional","affiliation":[]},{"given":"Lore","family":"Zech","sequence":"additional","affiliation":[]},{"given":"Bengt","family":"Glimelius","sequence":"additional","affiliation":[]},{"given":"Christer","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2006,7,17]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1182\/blood.V82.8.2289.2289","article-title":"p53 mutations are associated with histologic transformation of follicular lymphoma","volume":"82","author":"Coco F. 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