{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T13:40:57Z","timestamp":1698327657352},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,10,20]],"date-time":"2005-10-20T00:00:00Z","timestamp":1129766400000},"content-version":"vor","delay-in-days":3886,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int J Imaging Syst Tech"],"published-print":{"date-parts":[[1995,3]]},"abstract":"Abstract<\/jats:title>The phase space of P<\/jats:italic>+<\/jats:sub>, describing the probability of achieving tumor control without causing severe complications in normal tissues, has been investigated for three different clinically relevant treatment geometries. These include tumors in the head and neck region, thorax, and pelvis. Some general conclusions about the shape and properties of the P<\/jats:italic>+<\/jats:sub> phase space are given for the selected target volumes. The use of three different radiation beam types\u2010strictly homogeneous, wedged, and generally nonuniform beams\u2010has been investigated and the considerable differences in the P<\/jats:italic>+<\/jats:sub> phase space are shown. One conclusion is that the exact selection of beam entry direction becomes gradually less important as the number of beam portals becomes larger. One of the most important results is that use of appropriately selected nonuniform beam profiles reduces the number of necessary beam portals to such a low level that the treatment technique becomes simple and reliable at the same time as the probability of achieving tumor control without severe complications is almost as high as with an unlimited number of beams This means that most ordinary treatment units equipped with beam compensating filters can be used for closely optimal radiation therapy.<\/jats:p>","DOI":"10.1002\/ima.1850060112","type":"journal-article","created":{"date-parts":[[2007,3,5]],"date-time":"2007-03-05T23:08:36Z","timestamp":1173136116000},"page":"91-103","source":"Crossref","is-referenced-by-count":12,"title":["Few\u2010field radiation therapy optimization in the phase space of complication\u2010free tumor control"],"prefix":"10.1002","volume":"6","author":[{"given":"Svante","family":"S\u00f6derstr\u00f6m","sequence":"first","affiliation":[]},{"given":"Anders","family":"Gustafsson","sequence":"additional","affiliation":[]},{"given":"Anders","family":"Brahme","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2005,10,20]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/37\/4\/005"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841868709092978"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841869009090028"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(90)90037-K"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/37\/4\/004"},{"key":"e_1_2_1_7_2","volume-title":"Radiation Therapy Physics","author":"Brahme A.","year":"1992"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1088\/0266-5611\/6\/3\/010"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.597302"},{"key":"e_1_2_1_10_2","unstructured":"A.GustafssonandA.Brahme \u201cSimultaneous optimization of dynamic multileaf collimation and scanning patterns or compensation filters using a generalized pencil beam algorithm\u201d submitted toMed. Phys."},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/33\/11\/007"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/39\/1\/003"},{"key":"e_1_2_1_13_2","unstructured":"ICRU 24 Determination of Absorbed Dose in a Patient Irradiated by Beams of X or Gamma rays in Radiotherapy Procedures (Bethesda) 1976."},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/02841867709134308"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/30\/9\/010"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1118\/1.596971"},{"key":"e_1_2_1_17_2","unstructured":"S.S\u00f6derstr\u00f6m AGustafsson andA.Brahme \u201cThe clinical value of different treatment objectives and degrees of freedom in radiation therapy optimization \u201d submitted to Radiother. Oncol."},{"key":"e_1_2_1_18_2","unstructured":"P.K\u00e4llman \u201cOptimization of radiation therapy planning using physical and biological objective functions \u201d thesis. Stockholm University Sweden 1992."},{"key":"e_1_2_1_19_2","unstructured":"B. K.LindandA.Brahme Optimization of radiation therapy dose distributions with scanned photon beams inThe Use of Computers in Radiation TherapyI. A. D. Bruinvis et al. eds. 1987 pp.235\u2013239."}],"container-title":["International Journal of Imaging Systems and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fima.1850060112","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ima.1850060112","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T21:18:06Z","timestamp":1698268686000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ima.1850060112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995,3]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1995,3]]}},"alternative-id":["10.1002\/ima.1850060112"],"URL":"https:\/\/doi.org\/10.1002\/ima.1850060112","archive":["Portico"],"relation":{},"ISSN":["0899-9457","1098-1098"],"issn-type":[{"value":"0899-9457","type":"print"},{"value":"1098-1098","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995,3]]}}}