{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:28:46Z","timestamp":1767850126793,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T00:00:00Z","timestamp":1605398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001703","name":"\u00c9cole Polytechnique F\u00e9d\u00e9rale de Lausanne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001703","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Int J Imaging Syst Tech"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>High\u2010throughput synchrotron\u2010based tomographic microscopy at third generation light sources allows to probe cm\u2010sized samples at micrometer\u2010resolution. In this work, we present an approach to image a full mouse brain. With Indian\u2010ink as a contrast agent, it was possible to obtain 3D distribution of microvessels while a computational framework automatically extracted the morphological and geometrical embedding of the putative vascular systems. Results demonstrate the potentiality of the proposed methodology to visualize and quantify in 3D details of the brain tissue with an image quality and resolution previously unachievable.<\/jats:p>","DOI":"10.1002\/ima.22520","type":"journal-article","created":{"date-parts":[[2020,11,16]],"date-time":"2020-11-16T06:22:48Z","timestamp":1605507768000},"page":"1211-1220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Brain micro\u2010vasculature imaging: An unsupervised deep learning algorithm for segmenting mouse brain volume probed by high\u2010resolution phase\u2010contrast X\u2010ray tomography"],"prefix":"10.1002","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5760-3118","authenticated-orcid":false,"given":"Alessandra","family":"Patera","sequence":"first","affiliation":[{"name":"Centre d'Imagerie BioMedicale Ecole Polytechnique Federale de Lausanne  Lausanne Switzerland"}]},{"given":"Antonio G.","family":"Zippo","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience  Milan Italy"}]},{"given":"Anne","family":"Bonnin","sequence":"additional","affiliation":[{"name":"Swiss Light Source Paul Scherrer Institute  Villigen Switzerland"}]},{"given":"Marco","family":"Stampanoni","sequence":"additional","affiliation":[{"name":"Swiss Light Source Paul Scherrer Institute  Villigen Switzerland"},{"name":"Institute of Biomedical Engineering University and ETH  Z\u00fcrich Switzerland"}]},{"given":"Gabriele E. M.","family":"Biella","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience  Milan Italy"}]}],"member":"311","published-online":{"date-parts":[[2020,11,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200008)44:2<252::AID-MRM12>3.0.CO;2-G"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06251-7"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000002151"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700694"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.09.044"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0709788105"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116523"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140454"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20829"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2018.02.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/2153-3539.109864"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep15051"},{"key":"e_1_2_10_14_1","volume-title":"Proc. SPIE 9041, Medical Imaging 2014: Digital Pathology, 90410G (20 March 2014)","author":"Xu Y","year":"2014"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3426"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00128"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.23.7.076501"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.11.014"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2008.12.030"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10178"},{"issue":"12573","key":"e_1_2_10_21_1","first-page":"1","article-title":"Whole\u2010brain vasculature reconstruction at the single capillary level","volume":"8","author":"Giovanna APD","year":"2018","journal-title":"Sci Rep."},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0613"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btz423"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088067"},{"key":"e_1_2_10_25_1","unstructured":"M Stampanoni A Groso A Isenegger"},{"key":"e_1_2_10_26_1","first-page":"38","volume-title":"AIP Conference Proceedings","author":"Mokso R","year":"2011"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40679-016-0035-9"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0909049512032864"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3934\/ipi.2016009"},{"key":"e_1_2_10_30_1","first-page":"315","volume-title":"Improving Clustering Algorithms for Image Segmentation Using Contour and Region Information","author":"Oliver A","year":"2006"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvcir.2016.11.003"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2105-13-316"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1145\/361237.361242"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-16687-7_41"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.12.3.207"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.78.4.431"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-05587-4"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0195-17.2017"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1088\/0022-3727\/46\/49\/494004"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep14982"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1107\/S0021889813025843"}],"container-title":["International Journal of Imaging Systems and Technology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ima.22520","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ima.22520","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ima.22520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:28:02Z","timestamp":1693326482000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ima.22520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,15]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/ima.22520"],"URL":"https:\/\/doi.org\/10.1002\/ima.22520","archive":["Portico"],"relation":{},"ISSN":["0899-9457","1098-1098"],"issn-type":[{"value":"0899-9457","type":"print"},{"value":"1098-1098","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,15]]},"assertion":[{"value":"2019-12-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}