{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:20:57Z","timestamp":1770891657273,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T00:00:00Z","timestamp":1362700800000},"content-version":"vor","delay-in-days":6094,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Journal of Clinical Pharma"],"published-print":{"date-parts":[[1996,7]]},"abstract":"<jats:p><jats:italic>The efficacy and safety of graded doses (10, 20, and 30 mg) of controlled\u2010release (CR) oxycodone was compared with that of immediate\u2010release (IR) oxycodone (15 mg), immediate\u2010release oxycodone 10 mg in combination with acetaminophen 650 mg (APAP), and placebo in a single\u2010dose, double\u2010blind, randomized, parallel\u2010group study. The participants, 182 inpatients experiencing moderate to severe pain after abdominal or gynecologic surgery, provided hourly ratings of pain intensity and relief for 12 hours after administration. All active treatments were significantly superior to placebo for many hourly measurements and for the sum of pain intensity differences (SPID) and total pain relief (TOTPAR). A dose response was found among the three levels of CR oxycodone for pain relief and peak pain intensity difference (PID), with the 20\u2010 and 30\u2010mg doses being significantly better than the 10\u2010mg dose. For all active treatments, peak PID and peak pain relief occurred approximately 2 to 4 hours after administration. The median time to onset of relief was 32 minutes for oxycodone plus APAP, 41 minutes for IR oxycodone, and 46 minutes for CR oxycodone 30 mg. Duration of pain relief showed that the 10\u2010, 20\u2010, and 30\u2010mg doses of CR oxycodone had durations of action of 10 to 12 hours compared with IR oxycodone and oxycodone plus APAP (both approximately 7 hours). Typical adverse events, particularly somnolence, occurred in all active treatment groups. Treatment with CR oxycodone was safe and effective in this study, and its characteristics will be beneficial in the treatment of pain<\/jats:italic>.<\/jats:p>","DOI":"10.1002\/j.1552-4604.1996.tb04223.x","type":"journal-article","created":{"date-parts":[[2013,3,8]],"date-time":"2013-03-08T18:44:56Z","timestamp":1362768296000},"page":"595-603","source":"Crossref","is-referenced-by-count":62,"title":["Analgesic Efficacy of Controlled\u2010Release Oxycodone in Postoperative Pain"],"prefix":"10.1002","volume":"36","author":[{"given":"Abraham","family":"Sunshine","sequence":"first","affiliation":[]},{"given":"Nancy Z.","family":"Olson","sequence":"additional","affiliation":[]},{"given":"Ariel","family":"Colon","sequence":"additional","affiliation":[]},{"given":"Juana","family":"Rivera","sequence":"additional","affiliation":[]},{"given":"Robert F.","family":"Kaiko","sequence":"additional","affiliation":[]},{"given":"Ronald D.","family":"Fitzmartin","sequence":"additional","affiliation":[]},{"given":"Robert F.","family":"Reder","sequence":"additional","affiliation":[]},{"given":"Paul D.","family":"Goldenheim","sequence":"additional","affiliation":[]}],"member":"311","published-online":{"date-parts":[[2013,3,8]]},"reference":[{"key":"e_1_2_1_2_2","first-page":"381","article-title":"Eukodal, a new anesthetic","author":"Falk E","year":"1917","journal-title":"Muenchener Medizinische Wochenschrift"},{"key":"e_1_2_1_3_2","volume-title":"Principles of Analgesic Use in the Treatment of Acute Pain and Cancer Pain","year":"1992"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(91)90046-7"},{"key":"e_1_2_1_5_2","first-page":"29","article-title":"Opioid analgesics in cancer pain: current practice and controversies","volume":"7","author":"Twycross RG","year":"1988","journal-title":"Cancer Surv"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0885-3924(93)90101-Z"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.5.973"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1992.176"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1992.tb04090.x"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.1989.tb05399.x"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.2"},{"key":"e_1_2_1_12_2","volume-title":"Goodman and Gilman's The Pharmacological Basis of Therapeutics","author":"Gilman AG","year":"1990"},{"key":"e_1_2_1_13_2","first-page":"92","article-title":"Analgesic studies of codeine and oxycodone in patients with cancer. I. Comparisons of oral with intramuscular codeine and of oral with intramuscular oxycodone","volume":"207","author":"Beaver WT","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_14_2","first-page":"527","article-title":"The use and misuse of narcotics in the treatment of chronic pain","volume":"4","author":"Houde RW","year":"1974","journal-title":"Adv Neurol"},{"key":"e_1_2_1_15_2","first-page":"75","volume-title":"Analgesics.","author":"Houde RW","year":"1965"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.1990.85"},{"key":"e_1_2_1_17_2","first-page":"101","article-title":"Analgesic studies of codeine and oxycodone in patients with cancer. II. Comparisons of intramuscular oxycodone with intramuscular morphine and codeine","volume":"207","author":"Beaver WT","year":"1978","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5769.287"},{"key":"e_1_2_1_19_2","first-page":"162","article-title":"A comparison of pethidine, piritramide and oxycodone in patients with pain following cholecystectomy","volume":"22","author":"Takki S","year":"1973","journal-title":"Anaesthesist"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/0030-4220(80)90430-2"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1991.tb03364.x"},{"key":"e_1_2_1_22_2","first-page":"390","volume-title":"Dose and effectiveness of oral oxycodone following PCA morphine for postoperative analgesia (abstract)","author":"Hood GM","year":"1993"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/52.6.613"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1986.tb02487.x"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1990.tb00838.x"},{"key":"e_1_2_1_26_2","volume-title":"Activities of the Addiction Research Center during 1965","author":"Martin WR","year":"1966"},{"key":"e_1_2_1_27_2","volume-title":"Experimental Design","author":"Cochran WG","year":"1957"},{"key":"e_1_2_1_28_2","volume-title":"Statistical Methods for the Analysis of Biomedical Data","author":"Woolson RF","year":"1987"},{"key":"e_1_2_1_29_2","first-page":"90","volume-title":"Simultaneous Statistical Inference.","author":"Rupert M","year":"1981"},{"key":"e_1_2_1_30_2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan EL","year":"1958","journal-title":"J Am Statistical Assoc"},{"key":"e_1_2_1_31_2","first-page":"55","volume-title":"Advances in Pain Research and Therapy","author":"Max MB","year":"1991"},{"key":"e_1_2_1_32_2","volume-title":"Guidelines for the Clinical Evaluation of Analgesic Drugs.","author":"Public Health Services, United States Food and Drug Administration","year":"1992"}],"container-title":["The Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fj.1552-4604.1996.tb04223.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/j.1552-4604.1996.tb04223.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T21:26:51Z","timestamp":1698355611000},"score":1,"resource":{"primary":{"URL":"https:\/\/accp1.onlinelibrary.wiley.com\/doi\/10.1002\/j.1552-4604.1996.tb04223.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,7]]},"references-count":31,"journal-issue":{"issue":"7","published-print":{"date-parts":[[1996,7]]}},"alternative-id":["10.1002\/j.1552-4604.1996.tb04223.x"],"URL":"https:\/\/doi.org\/10.1002\/j.1552-4604.1996.tb04223.x","archive":["Portico"],"relation":{},"ISSN":["0091-2700","1552-4604"],"issn-type":[{"value":"0091-2700","type":"print"},{"value":"1552-4604","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,7]]}}}