{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T01:00:24Z","timestamp":1760576424941,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,11]],"date-time":"2006-01-11T00:00:00Z","timestamp":1136937600000},"content-version":"vor","delay-in-days":5093,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[1992,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study investigated if the attenuation in cephaloridine toxicity associated with streptozotocin (STZ)\u2010induced diabetes can be attributed to a direct cellular effect. Comparative studies examined the direct toxicity of cephaloridine 14 days after (35 mg kg<jats:sup>\u22121<\/jats:sup>, i.p.) STZ or vehicle injection of male Fischer 344 (F344) rats. <jats:italic>In vitro<\/jats:italic> cephaloridine toxicity was assessed by measuring lipid peroxidation, renal gluconeogenesis and organic ion accumulation in renal cortical slices. The <jats:italic>in vitro<\/jats:italic> toxicity of cephaloridine was reduced in the diabetic group since lipid peroxidation was not increased following a 120\u2010min exposure to cephaloridine. This was in contrast to a concentration\u2010 and time\u2010dependent increase in lipid peroxidation in renal tissue derived from normoglycemic animals pre\u2010incubated with 0\u20135 mM cephaloridine. Renal gluconeogenesis was inhibited in a concentration\u2010dependent manner in the normoglycemic group following a 15\u201390\u2010min exposure to 0\u20135 mM cephaloridine. Pyruvate\u2010stimulated gluconeogenesis was diminished in the diabetic group only after a 90\u2010min preincubation. Renal cortical slice accumulation of <jats:italic>p<\/jats:italic>\u2010aminohippurate (PAH) and tetraethylammonium (TEA) was decreased in the normoglycemic group. Accumulation of TEA, but not PAH, was decreased (<jats:italic>P<\/jats:italic> &lt; 0.05) in the diabetic group. These results indicate that <jats:italic>in vitro<\/jats:italic> cephaloridine toxicity was attenuated by STZ\u2010induced diabetes.<\/jats:p>","DOI":"10.1002\/jat.2550120106","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T03:08:13Z","timestamp":1160968093000},"page":"19-24","source":"Crossref","is-referenced-by-count":5,"title":["Comparative studies of <i>in vitro<\/i> renal cephaloridine toxicity between normoglycemic and diabetic rats"],"prefix":"10.1002","volume":"12","author":[{"given":"Monica A.","family":"Valentovic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William","family":"Jeffrey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John G.","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dianne","family":"Bailly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Morenas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Kinder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1,11]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(89)90165-0"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.33"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252690"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.bi.52.070183.003153"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90291-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(82)90052-7"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(83)90246-6"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(86)90171-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(66)90050-0"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/122.1-2.33"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(86)90303-0"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/0005-2760(85)90014-1"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483X(85)90063-0"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(59)90414-X"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(87)90291-2"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(87)90034-8"},{"key":"e_1_2_1_18_2","first-page":"165","article-title":"Lipid peroxides and \u03b1\u2010Tocopherol in rat streptozotocin induced diabetes mellitus","volume":"36","author":"Higuchi Y.","year":"1982","journal-title":"Acta Med. 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