{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:08:23Z","timestamp":1766268503603},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2001,7,18]],"date-time":"2001-07-18T00:00:00Z","timestamp":995414400000},"content-version":"vor","delay-in-days":198,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Biochem &amp; Molecular Tox"],"published-print":{"date-parts":[[2001,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Squalene monohydroperoxide (Sq\u2010OOH), the initial product of ultraviolet\u2010peroxidated squalene, was used to investigate the effect of peroxidative challenge upon the glutathione contents in rabbit ear skin and primary\u2010cultured fibroblasts derived from rabbit ear skin. The cellular reduced glutathione (GSH) contents decreased during 30\u2010minute incubations in vitro with Sq\u2010OOH, and oxidized glutathione (GSSG) was formed concomitantly, indicating that Sq\u2010OOH had a potential for GSH\u2010depleting activity in vitro. When Sq\u2010OOH was applied topically to the skin in vivo, only GSSG contents increased significantly within 30 minutes. Moreover, pretreatment with the GSH depletors, <jats:sc>DL<\/jats:sc>\u2010buthionine sulfoximine (BSO) and diethyl maleate (DEM), could potentiate the cytotoxicity and comedogenicity induced by Sq\u2010OOH. These findings suggest that the endogenous antioxidant, glutathione, is quite sensitive to Sq\u2010OOH and may be an important material for protecting cells and\/or tissues against the oxidative stress induced by Sq\u2010OOH treatment. \u00a9 2001 John Wiley &amp; Sons, Inc. 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