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We therefore administrated rats with clinically relevant doses of fluoxetine for a period of 6 months. DXA scans were performed during the treatment period in order to follow parameters as body weight, fat percentage and BMD. After 6 months of treatment, femurs were used to analyze bone architecture and bone strength, by means of \u00b5CT scans and three\u2010point bending assays, respectively. We found a slightly diminished bone quality, reflected in a lower bone tissue strength, which was compensated by changes in bone geometry. As leptin and adiponectin could be possible factors in the serotonergic regulation of bone metabolism, we also determined the levels of these factors in plasma samples of all animals. Leptin and adiponectin levels were not different between the control group and fluoxetine\u2010treated group, indicating that these factors were not involved in the observed changes in bone geometry and quality. J. Cell. Biochem. 101: 360\u2013368, 2007. \u00a9 2006 Wiley\u2010Liss, Inc.<\/jats:p>","DOI":"10.1002\/jcb.21177","type":"journal-article","created":{"date-parts":[[2006,12,12]],"date-time":"2006-12-12T20:53:15Z","timestamp":1165956795000},"page":"360-368","source":"Crossref","is-referenced-by-count":38,"title":["Long\u2010term fluoxetine administration does not result in major changes in bone architecture and strength in growing rats"],"prefix":"10.1002","volume":"101","author":[{"given":"I.","family":"Westbroek","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.H.","family":"Waarsing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.P.T.M.","family":"van 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