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Important carriers of stage\u2010specific carbohydrates are the lactoseries structure (Gal\u03b21\u21924GlcNAc) and the globoseries structure (Gal\u03b11\u21924Gal). Notably, the glycoprotein\u2010bound large carbohydrate of poly\u2010N\u2010acetyllactosamine\u2010type ([Gal\u03b21\u21924GlcNAc\u03b21 \u2192 3]<jats:sub>n<\/jats:sub>) carries a number of markers preferentially expressed in early embryonic cells. These markers are of practical value in analyzing embryogenesis and cell differentiation. For example, in order to monitor in vitro differentiation of multipotential embryonal carcinoma cells, stage\u2010specific embryonic antigen\u20101 (SSEA\u20101) and the <jats:italic>Lotus<\/jats:italic> agglutinin receptor have been used as markers of the undifferentiated cells, and the <jats:italic>Dolichos<\/jats:italic> agglutinin receptor has been used as a marker of extraembryonic endoderm cells. Developmental control of cell surface carbohydrates is attained by controlled expression of activities of key glycosyltransferases; for example, the activity of N\u2010acetylglucosaminide \u03b1l \u2192 3 fucosyltransferase is lost during in vitro differentiation of embryonal carcinoma cells to parietal endoderm cells, in parallel to the disappearance of SSEA\u20101. Accumulating evidence suggests that poly\u2010N\u2010acetyllactosamine\u2010type glycans that are abundant in early embryonic cells are involved in cell surface recognition of these cells.<\/jats:p>","DOI":"10.1002\/jcb.240360102","type":"journal-article","created":{"date-parts":[[2004,12,30]],"date-time":"2004-12-30T15:40:12Z","timestamp":1104421212000},"page":"1-14","source":"Crossref","is-referenced-by-count":96,"title":["Developmentally regulated expression of cell surface carbohydrates during mouse 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